Synaptic P2X receptors

被引:102
作者
Robertson, SJ
Ennion, SJ
Evans, RJ
Edwards, FA
机构
[1] Kings Coll London, Acad Dept Neurosurg, London SE5 9PJ, England
[2] Univ Leicester, Dept Cell Physiol & Pharmacol, Leicester LE1 9HN, Leics, England
[3] UCL, Dept Physiol, London WC1E 6BT, England
基金
英国惠康基金;
关键词
D O I
10.1016/S0959-4388(00)00222-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Over the past two years, ATP has clearly been shown to act as a co-transmitter with GABA, glycine and probably glutamate in the central nervous system. Our understanding of the ATP-gated P2X receptors is progressing rapidly, and the pharmacology, stoichiometry and subunit combinations of heteropolymeric P2X channels has been substantially elucidated.
引用
收藏
页码:378 / 386
页数:9
相关论文
共 79 条
  • [61] An ambiguous fast synapse: a new twist in the tale of two transmitters
    Salter, MW
    De Koninck, Y
    [J]. NATURE NEUROSCIENCE, 1999, 2 (03) : 199 - 200
  • [62] Differential role of ionotropic glutamatergic mechanisms in responses to NTS P2x and A2a receptor stimulation
    Scislo, TJ
    O'Leary, DS
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2000, 278 (06): : H2057 - H2068
  • [63] Evidence that multiple P2X purinoceptors are functionally expressed in rat supraoptic neurones
    Shibuya, I
    Tanaka, K
    Hattori, Y
    Uezono, Y
    Harayama, N
    Noguchi, J
    Ueta, Y
    Izumi, F
    Yamashita, H
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1999, 514 (02): : 351 - 367
  • [64] Identification of amino acids within the P2X2 receptor C-terminus that regulate desensitization
    Smith, FM
    Humphrey, PPA
    Murrell-Lagnado, RD
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1999, 520 (01): : 91 - 99
  • [65] Altered cytokine production in mice lacking P2X7 receptors
    Solle, M
    Labasi, J
    Perregaux, DG
    Stam, E
    Petrushova, N
    Koller, BH
    Griffiths, RJ
    Gabel, CA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (01) : 125 - 132
  • [66] Activation of ATP receptor increases the cytosolic Ca2+ in nucleus accumbens neurons of rat brain
    Sorimachi, M
    Moritoyo, T
    Yamagami, K
    [J]. BRAIN RESEARCH, 2000, 882 (1-2) : 217 - 220
  • [67] Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors
    Souslova, V
    Cesare, P
    Ding, YN
    Akopian, AN
    Stanfa, L
    Suzuki, R
    Carpenter, K
    Dickenson, A
    Boyce, S
    Hill, R
    Nebenius-Oosthuizen, D
    Smith, AJH
    Kidd, EJ
    Wood, JN
    [J]. NATURE, 2000, 407 (6807) : 1015 - 1017
  • [68] Response of Schwann cells to action potentials in development
    Stevens, B
    Fields, RD
    [J]. SCIENCE, 2000, 287 (5461) : 2267 - 2271
  • [69] Contribution of individual subunits to the multimeric P2X2 receptor:: Estimates based on methanethiosulfonate block at T336C
    Stoop, R
    Thomas, S
    Rassendren, F
    Kawashima, E
    Buell, G
    Surprenant, A
    North, RA
    [J]. MOLECULAR PHARMACOLOGY, 1999, 56 (05) : 973 - 981
  • [70] The cytolytic P-2Z receptor for extracellular ATP identified as a P-2X receptor (P2X(7))
    Surprenant, A
    Rassendren, F
    Kawashima, E
    North, RA
    Buell, G
    [J]. SCIENCE, 1996, 272 (5262) : 735 - 738