REST acts through multiple deacetylase complexes

被引:20
作者
Griffith, EC
Greenberg, ME
机构
[1] Childrens Hosp, Div Neurosci, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA
关键词
D O I
10.1016/S0896-6273(01)00386-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The RE1 binding silencer protein REST represses neuronal-specific gene expression in nonneuronal cell types. In this issue of Neuron, Ballas et al. show that REST inhibits gene expression via the recruitment of multiple histone deacetylase complexes.
引用
收藏
页码:339 / 340
页数:2
相关论文
共 12 条
[1]   CoREST:: A functional corepressor required for regulation of neural-specific gene expression [J].
Andrés, ME ;
Burger, C ;
Peral-Rubio, MJ ;
Battaglioli, E ;
Anderson, ME ;
Grimes, J ;
Dallman, J ;
Ballas, N ;
Mandel, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (17) :9873-9878
[2]   Regulation of neuronal traits by a novel transcriptional complex [J].
Ballas, N ;
Battaglioli, E ;
Atouf, F ;
Andres, ME ;
Chenoweth, J ;
Anderson, ME ;
Burger, C ;
Moniwa, M ;
Davie, JR ;
Bowers, WJ ;
Federoff, HJ ;
Rose, DW ;
Rosenfeld, MG ;
Brehm, P ;
Mandel, G .
NEURON, 2001, 31 (03) :353-365
[3]   NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis [J].
Chen, ZF ;
Paquette, AJ ;
Anderson, DJ .
NATURE GENETICS, 1998, 20 (02) :136-142
[4]   REST - A MAMMALIAN SILENCER PROTEIN THAT RESTRICTS SODIUM-CHANNEL GENE-EXPRESSION TO NEURONS [J].
CHONG, JHA ;
TAPIARAMIREZ, J ;
KIM, S ;
TOLEDOARAL, JJ ;
ZHENG, YC ;
BOUTROS, MC ;
ALTSHULLER, YM ;
FROHMAN, MA ;
KRANER, SD ;
MANDEL, G .
CELL, 1995, 80 (06) :949-957
[5]   The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex [J].
Grimes, JA ;
Nielsen, SJ ;
Battaglioli, E ;
Miska, EA ;
Speh, JC ;
Berry, DL ;
Atouf, F ;
Holdener, BC ;
Mandel, G ;
Kouzarides, T .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (13) :9461-9467
[6]   Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes [J].
Huang, YF ;
Myers, SJ ;
Dingledine, R .
NATURE NEUROSCIENCE, 1999, 2 (10) :867-872
[7]   Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1 [J].
Humphrey, GW ;
Wang, YH ;
Russanova, VR ;
Hirai, T ;
Qin, J ;
Nakatani, Y ;
Howard, BH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (09) :6817-6824
[8]   Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes [J].
Naruse, Y ;
Aoki, T ;
Kojima, T ;
Mori, N .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (24) :13691-13696
[9]  
Palm K, 1998, J NEUROSCI, V18, P1280
[10]   Constitutive expression of the neuron-restrictive silencer factor (NRSF)/REST in differentiating neurons disrupts neuronal gene expression and causes axon pathfinding errors in vivo [J].
Paquette, AJ ;
Perez, SE ;
Anderson, DJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (22) :12318-12323