Oxidative damage mediated by Herbicides on yeast cells

被引：19

作者：

Braconi, Daniela ^{[1
]}

Possenti, Silvia ^{[1
]}

Laschi, Marcella ^{[1
]}

Geminiani, Michela ^{[1
]}

Lusini, Paola ^{[1
]}

Bernardini, Giulia ^{[1
]}

Santucci, Annalisa ^{[1
]}

机构：

[1] Univ Siena, Dipartimento Biol Mol, I-53100 Siena, Italy

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2008年 / 56卷 / 10期

关键词：

herbicides; oxidative stress; protein carbonylation; thiol oxidation; wine yeast;

D O I：

10.1021/jf800074p

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Agricultural herbicides are among the most commonly used pesticides worldwide, posing serious concerns for both humans, exposed to these chemicals through many routes, and the environment. To clarify the effects of three herbicides as commercial formulations (namely, Pointer, Silglif, and Proper Energy), parameters related to oxidative issues were investigated on an autochthonous wine yeast strain. It was demonstrated that herbicides were able to affect the enzymatic activities of catalase and superoxide dismutase, as well as to induce carbonylation and thiol oxidation as post-translational modifications of proteins. Saccharomyces cerevisiae is an optimal model system to study responses to xenobiotics and oxidative stress. Thus, the results obtained could further the understanding of mechanisms underlying the toxicity of herbicides.

引用

页码：3836 / 3845

页数：10

共 45 条

[1] Caloric restriction augments ROS defense in S-cerevisiae, by a Sir2p independent mechanism [J].