Effect of the herbicide glyphosate on liver lipoperoxidation in pregnant rats and their fetuses

被引：103

作者：

Beuret, CJ ^{[1
]}

Zirulnik, F ^{[1
]}

Giménez, MS ^{[1
]}

机构：

[1] Univ Nacl San Luis, Fac Quim Bioquim & Farm, Area Quim Biol, Catedra Bioquim Mol, RA-5700 San Luis, Argentina

来源：

REPRODUCTIVE TOXICOLOGY | 2005年 / 19卷 / 04期

关键词：

glyphosate; herbicide; lipoperoxidation; liver; pregnancy; fetus; rat;

D O I：

10.1016/j.reprotox.2004.09.009

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Glyphosate is a post-emergence herbicide that acts on the synthesis of amino acids and other endogenous metabolites in plants. It is commonly used in agriculture, forestry, and nurseries for the control or destruction of herbaceous plants. Metabolic processes during development and pregnancy could be sensitive to changes induced by glyphosate such as lipid peroxidation. The present study has investigated the effects that 1% glyphosate oral exposure has on lipoperoxidation and antioxidant enzyme systems in the maternal serum and liver of pregnant rats and their term fetuses at 21 days of gestation. The results suggest that excessive lipid peroxidation induced with glyphosate ingestion leads to an overload of maternal and fetal antioxidant defense systems. (c) 2004 Elsevier Inc. All rights reserved.

引用

页码：501 / 504

页数：4

共 24 条

[1]

AEBI H, 1984, METHOD ENZYMOL, V105, P121

[2] In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides [J].

Bagchi, D ;

Bagchi, M ;

Hassoun, EA ;

Stohs, SJ .

TOXICOLOGY, 1995, 104 (1-3) :129-140

[3]

Buege J A, 1978, Methods Enzymol, V52, P302

[4] DEVELOPMENTAL TOXICITY OF DINITROANILINE HERBICIDES IN RATS AND RABBITS .1. TRIFLURALIN [J].

BYRD, RA ;

MARKHAM, JK ;

EMMERSON, JL .

FUNDAMENTAL AND APPLIED TOXICOLOGY, 1995, 26 (02) :181-190

[5] Non-enzymatic peroxidation of lipids isolated from rat liver microsomes, mitochondria and nuclei [J].

Catala, A ;

Cerruti, A .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1997, 29 (03) :541-546

[6] Effect of the herbicide glyphosate on enzymatic activity in pregnant rats and their fetuses [J].

Daruich, J ;

Zirulnik, F ;

Gimenez, MS .

ENVIRONMENTAL RESEARCH, 2001, 85 (03) :226-231

[7]

FLOHE L, 1984, METHOD ENZYMOL, V105, P114

[8] Old enzymes for a new job - Herbicide detoxification in plants [J].

Kreuz, K ;

Tommasini, R ;

Martinoia, E .

PLANT PHYSIOLOGY, 1996, 111 (02) :349-353

[9] Gender and maturation affect glutathione status in human neonatal tissues [J].

Lavoie, JC ;

Chessex, P .

FREE RADICAL BIOLOGY AND MEDICINE, 1997, 23 (04) :648-657

[10] Genotoxicity and oxidative stress induced by pesticide exposure in bovine lymphocyte cultures in vitro [J].

Lioi, MB ;

Scarfi, MR ;

Santoro, A ;

Barbieri, R ;

Zeni, O ;

Di Berardino, D ;

Ursini, MV .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1998, 403 (1-2) :13-20

← 1 2 3 →