A live attenuated West Nile virus strain as a potential veterinary vaccine

被引：50

作者：

Lustig, S

Olshevsky, U

Ben-Nathan, D

Lachmi, BE

Malkinson, M

Kobiler, D

Halevy, M

机构：

[1] Israel Inst Biol Res, Dept Infect Dis, IL-7400 Ness Ziona, Israel

[2] Minist Agr & Rural Dev, Kimron Vet Inst, Div Avian Dis, Beit Dagan, Israel

来源：

VIRAL IMMUNOLOGY | 2000年 / 13卷 / 04期

关键词：

D O I：

10.1089/vim.2000.13.401

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This article reviews the development of two attenuated West Nile virus (WNV) variants, WNI-25 and WNI-25A. These variants have lost the neuroinvasion trait of the parental virus. Attenuation was achieved through serial passages in mosquito cells and neutralization escape from WNV-specific monoclonal antibody. Genetic analysis reveals amino acid changes between the parental and each of the variants. The attenuated variants preserve the ability to replicate in mice and geese and to induce a protective immune response. WNI-25A was found to be a genetically stable virus. This variant was successfully used as a live vaccine to protect geese against a wild-type virulent WNV field isolate that closely resembles the WNV isolated during the 1999 New York epidemic.

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收藏

页码：401 / 410

页数：10

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