Relationship between sulfate groups and biological activities of fucans

被引：196

作者：

Haroun-Bouhedja, F

Ellouali, M

Sinquin, C

Boisson-Vidal, C

机构：

[1] Univ Paris 13, Inst Galilee, Lab Rech Macromol, CNRS UMR 7540,IFREMER,URM2, FR-93430 Villetaneuse, France

[2] Univ Cadi Ayyad, FST Beni Mellal, Lab Valorisat Prod Alimentaires, Beni Mellal, Maroc, France

[3] IFREMER, Lab Biochim & Mol Marines, Unite Rech Marine 2, CNRS, F-44311 Nantes, France

来源：

THROMBOSIS RESEARCH | 2000年 / 100卷 / 05期

关键词：

fucans; sulfate content dependence; anticoagulant activity; antiproliferative activity;

D O I：

10.1016/S0049-3848(00)00338-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The anticoagulant and antiproliferative effects of low molecular weight fucans with different sulfate content were examined. The anticoagulant activity was determined by activated partial thromboplastin time and the antiproliferative one was achieved in vitro on CCL39 fibroblast cell line. The results showed that inhibitory effects of fucans on both coagulation and cell proliferation are dependent on their sulfation degree. Decreased sulfation diminishes the two activities not in the same manner: some low molecular weight fucan fractions with no anticoagulant activity retain their ability to inhibit cell growth. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：453 / 459

页数：7

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