The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

被引:110
作者
Eftekhari, Aziz [1 ]
Dizaj, Solmaz Maleki [2 ]
Sharifi, Simin [2 ]
Salatin, Sara [3 ]
Saadat, Yalda Rahbar [4 ]
Vahed, Sepideh Zununi [5 ]
Samiei, Mohammad [6 ]
Ardalan, Mohammadreza [5 ]
Rameshrad, Maryam [7 ]
Ahmadian, Elham [5 ,8 ]
Cucchiarini, Magali [9 ]
机构
[1] Maragheh Univ Med Sci, Pharmacol & Toxicol Dept, Maragheh 5515878151, Iran
[2] Tabriz Univ Med Sci, Dent & Periodontal Res Ctr, Tabriz 5166614756, Iran
[3] Tabriz Univ Med Sci, Fac Pharm, Dept Pharmaceut Nanotechnol, Tabriz 5166614756, Iran
[4] Tabriz Univ Med Sci, Nutr Res Ctr, Tabriz 5166614756, Iran
[5] Tabriz Univ Med Sci, Kidney Res Ctr, Tabriz 5166614756, Iran
[6] Tabriz Univ Med Sci, Fac Dent, Tabriz 5166614756, Iran
[7] North Khorasan Univ Med Sci, Nat Prod & Med Plants Res Ctr, Bojnurd 9414975516, Iran
[8] Tabriz Univ Med Sci, Student Res Comm, Tabriz 5166614756, Iran
[9] Saarland Univ, Med Ctr, Ctr Expt Orthopaed, D-66421 Homburg, Germany
关键词
nanomaterial; cartilage tissue engineering; regenerative medicine; MESENCHYMAL STEM-CELLS; AUTOLOGOUS CHONDROCYTE IMPLANTATION; ARTICULAR-CARTILAGE; IN-VITRO; CHONDROGENIC DIFFERENTIATION; COMPOSITE SCAFFOLD; POLYURETHANE SCAFFOLDS; OSTEOCHONDRAL DEFECTS; MECHANICAL-BEHAVIOR; POLYMER SCAFFOLDS;
D O I
10.3390/ijms21020536
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
The repair and regeneration of articular cartilage represent important challenges for orthopedic investigators and surgeons worldwide due to its avascular, aneural structure, cellular arrangement, and dense extracellular structure. Although abundant efforts have been paid to provide tissue-engineered grafts, the use of therapeutically cell-based options for repairing cartilage remains unsolved in the clinic. Merging a clinical perspective with recent progress in nanotechnology can be helpful for developing efficient cartilage replacements. Nanomaterials, < 100 nm structural elements, can control different properties of materials by collecting them at nanometric sizes. The integration of nanomaterials holds promise in developing scaffolds that better simulate the extracellular matrix (ECM) environment of cartilage to enhance the interaction of scaffold with the cells and improve the functionality of the engineered-tissue construct. This technology not only can be used for the healing of focal defects but can also be used for extensive osteoarthritic degenerative alterations in the joint. In this review paper, we will emphasize the recent investigations of articular cartilage repair/regeneration via biomaterials. Also, the application of novel technologies and materials is discussed.
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页数:24
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