Dipyridophenazine complexes of cobalt(III) and nickel(II): DNA-Binding and photocleavage studies

被引：162

作者：

Arounaguiri, S ^{[1
]}

Maiya, BG ^{[1
]}

机构：

[1] UNIV HYDERABAD, SCH CHEM, HYDERABAD 500046, ANDHRA PRADESH, INDIA

来源：

INORGANIC CHEMISTRY | 1996年 / 35卷 / 14期

关键词：

D O I：

10.1021/ic9508684

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Results of absorption titration, thermal denaturation, and differential pulse voltammetric experiments suggest that [Co(phen)(2)DPPZ](3+) and [Ni(phen)(2)DPPZ](2+) (phen = 1, 10-phenanthroline and DPPZ = dipyrido[3,2-a:2',3'-c]phenazine) are both avid binders of calf thymus DNA. On the other hand, while the cobalt(III) complex has been found to effect the photocleavage of the supercoiled pBR 322 DNA, the nickel(II) complex is ineffective under similar experimental conditions.

引用

页码：4267 / +

页数：1

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