Linking extracellular survival signals and the apoptotic machinery

被引：70

作者：

Nuñez, G

del Peso, L

机构：

[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1998年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0959-4388(98)80089-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The survival of cells in multicellular organisms requires continuous stimulation from the extracellular environment. The phosphatidylinositol-3' kinase/Akt signaling cascade has been identified as a critical pathway for the transduction of extracellular survival signals. The finding that the pro-apoptotic protein BAD is a substrate of Akt/PKB has provided the first link between extracellular survival signals and the apoptotic machinery.

引用

收藏

页码：613 / 618

页数：6

相关论文

共 60 条

[1] Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase [J].

Ahmed, NN ;

Grimes, HL ;

Bellacosa, A ;

Chan, TO ;

Tsichlis, PN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) :3627-3632

[2] The activation of p38 and apoptosis by the inhibition of ERK is antagonized by the phosphoinositide S-kinase/Akt pathway [J].

Berra, E ;

Diaz-Meco, MT ;

Moscat, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (17) :10792-10797

[3]

Blagosklonny MV, 1997, CANCER RES, V57, P130

[4] Fas- or ceramide-induced apoptosis is mediated by a rad-regulated activation of jun N-terminal kinase p38 kinases and GADD153 [J].

Brenner, B ;

Koppenhoefer, U ;

Weinstock, C ;

Linderkamp, O ;

Lang, F ;

Gulbins, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (35) :22173-22181

[5]

CLEVELAND JL, 1994, ONCOGENE, V9, P2217

[6] Caspases: the executioners of apoptosis [J].

Cohen, GM .

BIOCHEMICAL JOURNAL, 1997, 326 :1-16

[7] INHIBITION OF GLYCOGEN-SYNTHASE KINASE-3 BY INSULIN-MEDIATED BY PROTEIN-KINASE-B [J].

CROSS, DAE ;

ALESSI, DR ;

COHEN, P ;

ANDJELKOVICH, M ;

HEMMINGS, BA .

NATURE, 1995, 378 (6559) :785-789

[8]

Crowder RJ, 1998, J NEUROSCI, V18, P2933

[9] Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery [J].

Datta, SR ;

Dudek, H ;

Tao, X ;

Masters, S ;

Fu, HA ;

Gotoh, Y ;

Greenberg, ME .

CELL, 1997, 91 (02) :231-241

[10] Isoenzymes of protein kinase C: Differential involvement in apoptosis and pathogenesis [J].

Deacon, EM ;

Pongracz, J ;

Griffiths, G ;

Lord, JM .

JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY, 1997, 50 (03) :124-131

← 1 2 3 4 5 6 →