Linking extracellular survival signals and the apoptotic machinery

被引：70

作者：

Nuñez, G

del Peso, L

机构：

[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1998年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0959-4388(98)80089-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The survival of cells in multicellular organisms requires continuous stimulation from the extracellular environment. The phosphatidylinositol-3' kinase/Akt signaling cascade has been identified as a critical pathway for the transduction of extracellular survival signals. The finding that the pro-apoptotic protein BAD is a substrate of Akt/PKB has provided the first link between extracellular survival signals and the apoptotic machinery.

引用

收藏

页码：613 / 618

页数：6

相关论文

共 60 条

[51] Phosphoinositide 3-kinases: A conserved family of signal transducers [J].

Vanhaesebroeck, B ;

Leevers, SJ ;

Panayotou, G ;

Waterfield, MD .

TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (07) :267-272

[52] Life, death, and the pursuit of apoptosis [J].

White, E .

GENES & DEVELOPMENT, 1996, 10 (01) :1-15

[53] Caspase-dependent cleavage of signaling proteins during apoptosis - A turn-off mechanism for anti-apoptotic signals [J].

Widmann, C ;

Gibson, S ;

Johnson, GL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (12) :7141-7147

[54] Endothelial apoptosis in Braf-deficient mice [J].

Wojnowski, L ;

Zimmer, AM ;

Beck, TW ;

Hahn, H ;

Bernal, R ;

Rapp, UR ;

Zimmer, A .

NATURE GENETICS, 1997, 16 (03) :293-297

[55] OPPOSING EFFECTS OF ERK AND JNK-P38 MAP KINASES ON APOPTOSIS [J].

XIA, ZG ;

DICKENS, M ;

RAINGEAUD, J ;

DAVIS, RJ ;

GREENBERG, ME .

SCIENCE, 1995, 270 (5240) :1326-1331

[56] Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase [J].

Xiong, WC ;

Parsons, JT .

JOURNAL OF CELL BIOLOGY, 1997, 139 (02) :529-539

[57] BAD, A HETERODIMERIC PARTNER FOR BCL-X(L) AND BCL-2, DISPLACES BAX AND PROMOTES CELL-DEATH [J].

YANG, E ;

ZHA, JP ;

JOCKEL, J ;

BOISE, LH ;

THOMPSON, CB ;

KORSMEYER, SJ .

CELL, 1995, 80 (02) :285-291

[58] REQUIREMENT FOR PHOSPHATIDYLINOSITOL-3 KINASE IN THE PREVENTION OF APOPTOSIS BY NERVE GROWTH-FACTOR [J].

YAO, RJ ;

COOPER, GM .

SCIENCE, 1995, 267 (5206) :2003-2006

[59] Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BGL-X(L) [J].

Zha, JP ;

Harada, H ;

Yang, E ;

Jockel, J ;

Korsmeyer, SJ .

CELL, 1996, 87 (04) :619-628

[60] Interleukin 3-dependent survival by the Akt protein kinase [J].

Zhou, SY ;

Baltimore, D ;

Cantley, LC ;

Kaplan, DR ;

Franke, TF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (21) :11345-11350

← 1 2 3 4 5 6 →