The FLT3ITD mRNA level has a high prognostic impact in NPM1 mutated, but not in NPM1 unmutated, AML with a normal karyotype

被引：37

作者：

Schneider, Friederike ^{[1
]}

Hoster, Eva ^{[1
,2
]}

Unterhalt, Michael ^{[1
]}

Schneider, Stephanie ^{[1
]}

Dufour, Annika ^{[1
]}

Benthaus, Tobias ^{[1
]}

Mellert, Gudrun ^{[1
]}

Zellmeier, Evelyn ^{[1
]}

Kakadia, Purvi M. ^{[1
]}

Bohlander, Stefan K. ^{[1
,3
]}

Feuring-Buske, Michaela ^{[4
]}

Buske, Christian ^{[5
]}

Braess, Jan ^{[1
]}

Heinecke, Achim ^{[6
]}

Sauerland, Maria C. ^{[6
]}

Berdel, Wolfgang E. ^{[7
]}

Buechner, Thomas ^{[7
]}

Woermann, Bernhard J. ^{[8
]}

Hiddemann, Wolfgang ^{[1
,3
]}

Spiekermann, Karsten ^{[1
,3
]}

机构：

[1] Univ Hosp Munich, Dept Med 3, Lab Leukemia Diagnost, Munich, Germany

[2] Univ Munich, Inst Med Stat Biometry & Epidemiol, Munich, Germany

[3] Helmholtz Ctr Munich, Clin Cooperat Grp Acute Leukemias, Munich, Germany

[4] Univ Ulm, Dept Internal Med 3, D-7900 Ulm, Germany

[5] Inst Expt Tumor Res, Comprehens Canc Ctr Ulm, Ulm, Germany

[6] Univ Munster, Inst Biostat & Clin Res, Munster, Germany

[7] Univ Munster, Dept Med Hematol & Oncol, Munster, Germany

[8] German Soc Hematol & Oncol, Berlin, Germany

来源：

BLOOD | 2012年 / 119卷 / 19期

关键词：

ACUTE MYELOID-LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; GENE-MUTATIONS; NUCLEOPHOSMIN; CYTOGENETICS;

D O I：

10.1182/blood-2010-12-327072

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The impact of a FLT3-internal tandem duplication (FLT3ITD) on prognosis of patients with acute myeloid leukemia (AML) is dependent on the ratio of mutated to wild-type allele. In 648 normal karyotype (NK) AML patients, we found a significant independent effect of the quantitative FLT3ITD mRNA level-measured as (FLT3ITD/wtFLT3)/(FLT3ITD/wtFLT3 + 1)-on outcome. Moreover, this effect was clearly seen in 329 patients with a mutated NPM1 gene (NPM1(+)), but not in 319 patients without a NPM1 mutation (wtNPM1). In a multivariate Cox regression model, the quantitative FLT3ITD mRNA level showed an independent prognostic impact on overall survival (OS) and relapse-free survival (RFS) only in the NPM1(+) subgroup (OS: hazard ratio, 5.9; [95% confidence interval [CI]: 3.1-11.2]; RFS: hazard ratio, 7.5 [95% CI: 3.4-16.5]). The FLT3ITD mRNA level contributes to relapse risk stratification and might help to guide postremission therapy in NPM1-mutated AML. (Blood. 2012;119(19):4383-4386)

引用

页码：4383 / 4386

页数：4

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