Leukotrienes as mediators of airway obstruction

被引:82
作者
Drazen, JM
机构
[1] Brigham & Womens Hosp, Div Pulm, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Med, Div Pulm, Boston, MA USA
关键词
D O I
10.1164/ajrccm.158.supplement_2.13tac180
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
The cysteinyl leukotrienes are potent mediators of airway narrowing derived from the lipoxygenation of arachidonic acid and the adduction of glutathione to this eicosanoid backbone. In lower animals and humans, the cysteinyl leukotrienes are among the most potent airway contractile substances ever identified. Furthermore, these moieties can be recovered from the urine during induced or spontaneous asthma attacks. Most important, inhibition of the synthesis of the leukotrienes or prevention of their action at the CysLT(1) receptor is associated with an improvement in the airway dysfunction that occurs in both induced and spontaneous asthma. These data indicate that the cysteinyl leukotrienes have a clinically significant role in the airway obstruction that characterizes asthma.
引用
收藏
页码:S193 / S200
页数:8
相关论文
共 140 条
[1]   AIRWAY RESPONSIVENESS TO LEUKOTRIENE-C4 AND LEUKOTRIENE-D4 AND TO METHACHOLINE IN PATIENTS WITH ASTHMA AND NORMAL CONTROLS [J].
ADELROTH, E ;
MORRIS, MM ;
HARGREAVE, FE ;
OBYRNE, PM .
NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (08) :480-484
[2]   DIURNAL-VARIATION OF URINARY LEUKOTRIENE E(4) AND HISTAMINE EXCRETION RATES IN NORMAL SUBJECTS AND PATIENTS WITH MILD-TO-MODERATE ASTHMA [J].
ASANO, K ;
LILLY, CM ;
ODONNELL, WJ ;
ISRAEL, E ;
FISCHER, A ;
RANSIL, BJ ;
DRAZEN, JM .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1995, 96 (05) :643-651
[3]  
BALCAREK JM, 1988, J BIOL CHEM, V263, P13937
[4]   COMPARATIVE EFFECTS OF INHALED LEUKOTRIENE-C4, LEUKOTRIENE-D4, AND HISTAMINE IN NORMAL HUMAN-SUBJECTS [J].
BARNES, NC ;
PIPER, PJ ;
COSTELLO, JF .
THORAX, 1984, 39 (07) :500-504
[5]   THE EFFECT OF INHALED BUDESONIDE ON THE MAXIMAL DEGREE OF AIRWAY NARROWING TO LEUKOTRIENE-D4 AND METHACHOLINE IN NORMAL SUBJECTS INVIVO [J].
BEL, EH ;
VANDERVEEN, H ;
DIJKMAN, JH ;
STERK, PJ .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1989, 139 (02) :427-431
[6]   EVIDENCE INDICATING THAT LEUKOTRIENE-C4, LEUKOTRIENE-D4 AND LEUKOTRIENE-E4 ARE MAJOR MEDIATORS OF CONTRACTION INDUCED BY ANTI-IGE IN HUMAN BRONCHI [J].
BJORCK, T ;
DAHLEN, SE .
AGENTS AND ACTIONS, 1989, 26 (1-2) :87-89
[7]  
BUCKNER CK, 1986, J PHARMACOL EXP THER, V237, P558
[8]   STRUCTURAL REQUIREMENTS FOR THE BINDING OF FATTY-ACIDS TO 5-LIPOXYGENASE-ACTIVATING PROTEIN [J].
CHARLESON, S ;
EVANS, JF ;
LEGER, S ;
PERRIER, H ;
PRASIT, P ;
WANG, ZY ;
VICKERS, PJ .
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1994, 267 (03) :275-280
[9]   URINARY LEUKOTRIENE-E4 CONCENTRATIONS INCREASE AFTER ASPIRIN CHALLENGE IN ASPIRIN-SENSITIVE ASTHMATIC SUBJECTS [J].
CHRISTIE, PE ;
TAGARI, P ;
FORDHUTCHINSON, AW ;
CHARLESSON, S ;
CHEE, P ;
ARM, JP ;
LEE, TH .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 143 (05) :1025-1029
[10]   THE POTENT AND SELECTIVE SULFIDOPEPTIDE LEUKOTRIENE ANTAGONIST, SK-AND-F-104353, INHIBITS ASPIRIN-INDUCED ASTHMA [J].
CHRISTIE, PE ;
SMITH, CM ;
LEE, TH .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 144 (04) :957-958