Leukotrienes as mediators of airway obstruction

被引:82
作者
Drazen, JM
机构
[1] Brigham & Womens Hosp, Div Pulm, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Med, Div Pulm, Boston, MA USA
关键词
D O I
10.1164/ajrccm.158.supplement_2.13tac180
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
The cysteinyl leukotrienes are potent mediators of airway narrowing derived from the lipoxygenation of arachidonic acid and the adduction of glutathione to this eicosanoid backbone. In lower animals and humans, the cysteinyl leukotrienes are among the most potent airway contractile substances ever identified. Furthermore, these moieties can be recovered from the urine during induced or spontaneous asthma attacks. Most important, inhibition of the synthesis of the leukotrienes or prevention of their action at the CysLT(1) receptor is associated with an improvement in the airway dysfunction that occurs in both induced and spontaneous asthma. These data indicate that the cysteinyl leukotrienes have a clinically significant role in the airway obstruction that characterizes asthma.
引用
收藏
页码:S193 / S200
页数:8
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