The glucose-regulated proteins: stress induction and clinical applications

被引：884

作者：

Lee, AS ^{[1
]}

机构：

[1] Univ So Calif, Keck Sch Med, Kenneth Norris Jr Comprehens Canc Ctr, Dept Biochem & Mol Biol, Los Angeles, CA 90089 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 08期

关键词：

D O I：

10.1016/S0968-0004(01)01908-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A protective mechanism used by cells to adapt to stress of the endoplasmic reticulum (ER) is the induction of members of the glucose-regulated protein (Grp) family. The induction of mammalian Grp proteins in response to ER stress involves a complex network of regulators and novel mechanisms. The elucidation cf Grp function and regulation opens up new therapeutic approaches to diseases associated with ER stress and cancer.

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页码：504 / 510

页数：7

相关论文

共 60 条

[1] Activation of the unfolded protein response pathway induces human asparagine synthetase gene expression [J].

Barbosa-Tessmann, IP ;

Chen, C ;

Zhong, C ;

Schuster, SM ;

Nick, HS ;

Kilberg, MS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (44) :31139-31144

[2] Glucose-regulated protein 78 (GRP78) is elevated in embryonic mouse heart and induced following hypoglycemic stress [J].

Barnes, JA ;

Smoak, IW .

ANATOMY AND EMBRYOLOGY, 2000, 202 (01) :67-74

[3] Increased sensitivity of human colon cancer cells to DNA cross-linking agents after GRP78 up-regulation [J].

Belfi, CA ;

Chatterjee, S ;

Gosky, DM ;

Berger, SJ ;

Berger, NA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (02) :361-368

[4] CD91: a receptor for heat shock protein gp96 [J].

Binder, RJ ;

Han, DK ;

Srivastava, PK .

NATURE IMMUNOLOGY, 2000, 1 (02) :151-155

[5] The sarco/endoplasmic reticulum calcium-ATPase 2b is an endoplasmic reticulum stress-inducible protein [J].

Caspersen, C ;

Pedersen, PS ;

Treiman, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (29) :22363-22372

[6]

Chavany C, 1996, J BIOL CHEM, V271, P4974

[7] Eradication of murine mammary adenocarcinoma through HSVtk expression directed by the glucose-starvation inducible grp78 promoter [J].

Chen, XK ;

Zhang, DX ;

Dennert, G ;

Hung, G ;

Lee, AS .

BREAST CANCER RESEARCH AND TREATMENT, 2000, 59 (01) :81-90

[8] Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions [J].

Fernandez, PM ;

Tabbara, SO ;

Jacobs, LK ;

Manning, FCR ;

Tsangaris, TN ;

Schwartz, AM ;

Kennedy, KA ;

Patierno, SR .

BREAST CANCER RESEARCH AND TREATMENT, 2000, 59 (01) :15-26

[9] The protein disulphide-isomerase family:: unravelling a string of folds [J].

Ferrari, DM ;

Söling, HD .

BIOCHEMICAL JOURNAL, 1999, 339 :1-10

[10] Conservation and divergence of the yeast and mammalian unfolded protein response -: Activation of specific mammalian endoplasmic reticulum stress element of the grp78/BiP promoter by yeast Hac1 [J].

Foti, DM ;

Welihinda, A ;

Kaufman, RJ ;

Lee, AS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (43) :30402-30409

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