Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes

被引：84

作者：

Pekarsky, Y

Hallas, C

Isobe, M

Russo, G

Croce, CM

机构：

[1] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[2] Toyama Univ, Toyama 9308555, Japan

[3] IRCCS, Ist Dermopat Immacolata, I-00167 Rome, Italy

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1999年 / 96卷 / 06期

关键词：

D O I：

10.1073/pnas.96.6.2949

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The TCL1 oncogene on human chromosome 14q32.1 is involved in the development of T cell leukemia in humans. Its expression in these Leukemias is activated by chromosomal translocations and inversions at 14q32.1. Here we report the isolation and characterization of a new member of the TCL1 gene family, TCL1b, located approximate to 16 kb centromeric of TCL1, The 1.2-kb TCL1b cDNA encodes a 14-kDa protein of 128 aa and shows 60% similarity to Tell. Expression profiles of TCL1 and TCL1b genes are very similar: both genes are expressed at very low levels in normal bone marrow and peripheral lymphocytes but are activated in T cell leukemia by rearrangements of the 14q32.1 region. Thus, translocations and inversions at 14q32.1 in T cell malignancies involve two oncogenes.

引用

页码：2949 / 2951

页数：3

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