IDENTIFICATION OF THE TCL1 GENE INVOLVED IN T-CELL MALIGNANCIES

被引：218

作者：

VIRGILIO, L

NARDUCCI, MG

ISOBE, M

BILLIPS, LG

COOPER, MD

CROCE, CM

RUSSO, G

机构：

[1] THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,JEFFERSON CANC CTR,PHILADELPHIA,PA 19107

[2] RAGGIO ITALGENE SPA,I-00040 POMEZIA,ITALY

[3] TOYAMA UNIV,FAC ENGN,CELLULAR & MOLEC BIOL LAB,TOYAMA 930,JAPAN

[4] UNIV ALABAMA,HOWARD HUGHES MED INST,BIRMINGHAM,AL 35294

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 26期

关键词：

CHROMOSOME; 14Q32.1; B-CELL DIFFERENTIATION; LYMPHOID MALIGNANCIES;

D O I：

10.1073/pnas.91.26.12530

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The TCL1 locus on chromosome 14q32.1 is frequently involved in chromosomal translocations and inversions with one of the T-cell receptor loci in human T-cell leukemias and lymphomas. The chromosome 14 region translocated or rearranged involves approximate to 350 kb of DNA at chromosome band 14q32.1. Within this region we have identified a gene coding for a 1.3-kb transcript, expressed only in restricted subsets of tells within the lymphoid lineage and expressed at high levels in leukemic cells carrying a t(14;14)(q11;q32) chromosome translocation or a inv(14)(q11;q32) chromosome inversion. The cognate cDNA sequence reveals an open reading frame of 342 nt encoding a protein of 14 kDa. The TCL1 gene sequence, which, to our knowledge, shows no sequence homology with other human genes, is preferentially expressed early in T- and B-lymphocyte differentiation.

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页码：12530 / 12534

页数：5

相关论文

共 33 条

[1] VARIANT TRANSLOCATION OF THE BCL-2 GENE TO IMMUNOGLOBULIN-LAMBDA LIGHT CHAIN GENE IN CHRONIC LYMPHOCYTIC-LEUKEMIA [J].

ADACHI, M ;

COSSMAN, J ;

LONGO, D ;

CROCE, CM ;

TSUJIMOTO, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) :2771-2774

[2] THE BREAKPOINT OF AN INVERSION OF CHROMOSOME-14 IN A T-CELL LEUKEMIA - SEQUENCES DOWNSTREAM OF THE IMMUNOGLOBULIN HEAVY-CHAIN LOCUS ARE IMPLICATED IN TUMORIGENESIS [J].

BAER, R ;

HEPPELL, A ;

TAYLOR, AMR ;

RABBITTS, PH ;

BOULLIER, B ;

RABBITTS, TH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (24) :9069-9073

[3] FUSION OF AN IMMUNOGLOBULIN VARIABLE GENE AND A T-CELL RECEPTOR CONSTANT GENE IN THE CHROMOSOME-14 INVERSION ASSOCIATED WITH T-CELL TUMORS [J].

BAER, R ;

CHEN, KC ;

SMITH, SD ;

RABBITTS, TH .

CELL, 1985, 43 (03) :705-713

[4] CHARACTERIZATION OF THE BREAKPOINT OF A T(14-14)(Q11.2-Q32) FROM THE LEUKEMIC-CELLS OF A PATIENT WITH T-CELL ACUTE LYMPHOBLASTIC-LEUKEMIA [J].

BERTNESS, VL ;

FELIX, CA ;

MCBRIDE, OW ;

MORGAN, R ;

SMITH, SD ;

SANDBERG, AA ;

KIRSCH, IR .

CANCER GENETICS AND CYTOGENETICS, 1990, 44 (01) :47-54

[5] INVERSIONS AND TANDEM TRANSLOCATIONS INVOLVING CHROMOSOME 14Q11 AND 14Q32 IN T-PROLYMPHOCYTIC LEUKEMIA AND T-CELL LEUKEMIAS IN PATIENTS WITH ATAXIA TELANGIECTASIA [J].

BRITOBABAPULLE, V ;

CATOVSKY, D .

CANCER GENETICS AND CYTOGENETICS, 1991, 55 (01) :1-9

[6] EXON AMPLIFICATION - A STRATEGY TO ISOLATE MAMMALIAN GENES BASED ON RNA SPLICING [J].

BUCKLER, AJ ;

CHANG, DD ;

GRAW, SL ;

BROOK, JD ;

HABER, DA ;

SHARP, PA ;

HOUSMAN, DE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :4005-4009

[7] GENE FOR ALPHA-CHAIN OF HUMAN T-CELL RECEPTOR - LOCATION ON CHROMOSOME-14 REGION INVOLVED IN T-CELL NEOPLASMS [J].

CROCE, CM ;

ISOBE, M ;

PALUMBO, A ;

PUCK, J ;

MING, J ;

TWEARDY, D ;

ERIKSON, J ;

DAVIS, M ;

ROVERA, G .

SCIENCE, 1985, 227 (4690) :1044-1047

[8] ROLE OF CHROMOSOME TRANSLOCATIONS IN HUMAN NEOPLASIA [J].

CROCE, CM .

CELL, 1987, 49 (02) :155-156

[9] TRANSCRIPTIONAL ACTIVATION OF AN UNREARRANGED AND UNTRANSLOCATED C-MYC ONCOGENE BY TRANSLOCATION OF A C-LAMBDA LOCUS IN BURKITT-LYMPHOMA CELLS [J].

CROCE, CM ;

THIERFELDER, W ;

ERIKSON, J ;

NISHIKURA, K ;

FINAN, J ;

LENOIR, GM ;

NOWELL, PC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (22) :6922-6926

[10] HUMAN C-MYC ONC GENE IS LOCATED ON THE REGION OF CHROMOSOME-8 THAT IS TRANSLOCATED IN BURKITT-LYMPHOMA CELLS [J].

DALLAFAVERA, R ;

BREGNI, M ;

ERIKSON, J ;

PATTERSON, D ;

GALLO, RC ;

CROCE, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (24) :7824-7827

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