TMC-1 A, B, C and D, new antibiotics of the manumycin group produced by Streptomyces sp - Taxonomy, production, isolation, physico-chemical properties, structure elucidation and biological properties

被引：31

作者：

Kohno, J ^{[1
]}

Nishio, M ^{[1
]}

Kawano, K ^{[1
]}

Nakanishi, N ^{[1
]}

Suzuki, S ^{[1
]}

Uchida, T ^{[1
]}

Komatsubara, S ^{[1
]}

机构：

[1] TANABE SEIYAKU CO LTD,LEAD OPTIMIZAT RES LAB,TODA,SAITAMA 335,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 12期

关键词：

D O I：

10.7164/antibiotics.49.1212

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Four new antitumor antibiotics, TMC-1 A, B, C and D were isolated from a fermentation broth of Streptomyces sp. A-230. Spectroscopic studies have shown that TMC-I A to D were new members of the manumycin class of antibiotics. These antibiotics showed cytotoxic activities against various tumor cell lines in vitro.

引用

页码：1212 / 1220

页数：9

共 16 条

[1] U-56,407, A NEW ANTIBIOTIC RELATED TO ASUKAMYCIN - ISOLATION AND CHARACTERIZATION [J].

BRODASKY, TF ;

STROMAN, DW ;

DIETZ, A ;

MIZSAK, S .

JOURNAL OF ANTIBIOTICS, 1983, 36 (08) :950-956

[2]

BUZZETTI F, 1963, PHARM ACTA HELV, V38, P871

[3] NUCLEAR MAGNETIC-RESONANCE ENANTIOMER REAGENTS - CONFIGURATIONAL CORRELATIONS VIA NUCLEAR MAGNETIC-RESONANCE CHEMICAL-SHIFTS OF DIASTEREOMERIC MANDELATE, O-METHYLMANDELATE, AND ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETATE (MTPA) ESTERS [J].

DALE, JA ;

MOSHER, HS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (02) :512-519

[4] ALISAMYCIN, A NEW ANTIBIOTIC OF THE MANUMYCIN GROUP .1. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL-ACTIVITY [J].

FRANCO, CMM ;

MAURYA, R ;

VIJAYAKUMAR, EKS ;

CHATTERJEE, S ;

BLUMBACH, J ;

GANGULI, BN .

JOURNAL OF ANTIBIOTICS, 1991, 44 (12) :1289-1293

[5] METABOLIC PRODUCTS OF MICROORGANISMS .244. COLABOMYCINS, NEW ANTIBIOTICS OF THE MANUMYCIN GROUP FROM STREPTOMYCES-GRISEOFLAVUS .1. ISOLATION, CHARACTERIZATION AND BIOLOGICAL PROPERTIES [J].

GROTE, R ;

ZEECK, A ;

DRAUTZ, H ;

ZAHNER, H .

JOURNAL OF ANTIBIOTICS, 1988, 41 (09) :1178-1185

[6] IDENTIFICATION OF RAS FARNESYLTRANSFERASE INHIBITORS BY MICROBIAL SCREENING [J].

HARA, M ;

AKASAKA, K ;

AKINAGA, S ;

OKABE, M ;

NAKANO, H ;

GOMEZ, R ;

WOOD, D ;

UH, M ;

TAMANOI, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (06) :2281-2285

[7] NISAMYCIN, A NEW MANUMYCIN GROUP ANTIBIOTIC FROM STREPTOMYCES SP K106 [J].

HAYASHI, K ;

NAKAGAWA, M ;

FUJITA, T ;

TANIMORI, S ;

NAKAYAMA, M .

JOURNAL OF ANTIBIOTICS, 1993, 46 (12) :1904-1907

[8] STRUCTURE OF ASUKAMYCIN, A POSSIBLE SHUNT METABOLITE FROM 3-DEHYDROQUINIC ACID IN THE SHIKIMATE PATHWAY [J].

KAKINUMA, K ;

IKEKAWA, N ;

NAKAGAWA, A ;

OMURA, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1979, 101 (12) :3402-3404

[9] RAPID COLORIMETRIC ASSAY FOR CELLULAR GROWTH AND SURVIVAL - APPLICATION TO PROLIFERATION AND CYTO-TOXICITY ASSAYS [J].

MOSMANN, T .

JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 65 (1-2) :55-63

[10] NEW COMPOUNDS OF THE MANUMYCIN GROUP OF ANTIBIOTICS AND A FACILITATED ROUTE FOR THEIR STRUCTURE ELUCIDATION [J].

SATTLER, I ;

GRONE, C ;

ZEECK, A .

JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (24) :6583-6587

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