Poly(oxyethylene) based surface coatings for poly(dimethylsiloxane) microchannels

被引：104

作者：

Hellmich, W ^{[1
]}

Regtmeier, J ^{[1
]}

Duong, TT ^{[1
]}

Ros, R ^{[1
]}

Anselmetti, D ^{[1
]}

Ros, A ^{[1
]}

机构：

[1] Univ Bielefeld, Fac Phys, D-4800 Bielefeld, Germany

来源：

LANGMUIR | 2005年 / 21卷 / 16期

关键词：

D O I：

10.1021/la0510432

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Control of surface properties in microfluidic systems is an indispensable prerequisite for successful bioanalytical applications. Poly(dimethylsiloxane) (PDMS) microfluidic devices are hampered from unwanted adsorption of biomolecules and lack of methods to control electroosmotic flow (EOF). In this paper, we propose different strategies to. coat PDMS surfaces with poly(oxyethylene) (POE) molecules of varying chain lengths. The native PDMS surface is pretreated by exposure to UV irradiation or to an oxygen plasma, and the covalent linkage of POE-silanes as well as physical adsorption of a triblock-copolymer (F108) are studied. Contact angle measurements and atomic force microscopy (AFM) imaging revealed homogeneous attachment of POE-silanes and F108 to the PDMS surfaces. In the case of F108, different adsorption mechanisms to hydrophilic and hydrophobic PDMS are discussed. Determination of the electroosmotic mobilities of these coatings in PDMS microchannels prove their use for electrokinetic applications in which EOF reduction is inevitable and protein adsorption has to be suppressed.

引用

页码：7551 / 7557

页数：7

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