Acylated pregnane glycosides from Caralluma tuberculata and their antiparasitic activity

被引：67

作者：

Abdel-Sattar, Essam ^{[1
]}

Harraz, Fathalla M. ^{[1
]}

Al-Ansari, Soliman Mohammed Abdullah ^{[2
]}

El-Mekkawy, Sahar ^{[3
]}

Ichino, Chikara ^{[4
]}

Kiyohara, Hiroaki ^{[4
]}

Ishiyama, Aki ^{[5
]}

Otoguro, Kazuhiko ^{[5
]}

Omura, Satoshi

Yamada, Haruki ^{[4
]}

机构：

[1] King Abdulaziz Univ, Dept Nat Prod & Alternat Med, Fac Pharm, Jeddah 21589, Saudi Arabia

[2] King Abdulaziz Univ, Dept Microbiol, Fac Med & Allied Sci, Jeddah 21589, Saudi Arabia

[3] Natl Res Ctr, Dept Chem Nat Cpds, Giza 12622, Egypt

[4] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

[5] Kitasato Inst, Res Ctr Trop Dis, Minato Ku, Tokyo 1088642, Japan

来源：

PHYTOCHEMISTRY | 2008年 / 69卷 / 11期

关键词：

Caralluma tuberculata; Asclepiadaceae; pregnane glycosides; antimalarial activity; antitrypanosomal activity; cytotoxicity;

D O I：

10.1016/j.phytochem.2008.05.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Five pregnane glycosides were isolated from Caralluma tuberculata (1-5), in addition to a known one (russelioside E, 6). The structures of the isolated compounds were elucidated by the analysis of NMR data and FAB-MS experiments. All the isolated compounds were tested for their antimalarial and antitrypanosomal activities as well as their cytotoxicity against human diploid embryonic cell line (MRC5). (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2180 / 2186

页数：7

共 29 条

[1]

New oxypregnane glycosides from Caralluma penicillata [J].

Abdel-Sattar, E ;

Meselhy, MR ;

Al-Yahya, MAA .

PLANTA MEDICA, 2002, 68 (05) :430-434

[2]

Penicillosides A-C, C-15 oxypregnane glycosides from Caralluma penicillata [J].

Abdel-Sattar, E ;

Al-Yahya, MAA ;

Nakamura, N ;

Hattori, M .

PHYTOCHEMISTRY, 2001, 57 (08) :1213-1217

[3]

Acylated pregnane glycosides from Caralluma russeliana [J].

Abdel-Sattar, Essam ;

Ahmed, Ahmed A. ;

Hegazy, Mohamed-Elamir F. ;

Farag, Mohamed A. ;

Al-Yahya, Mohammad Abdul-Aziz .

PHYTOCHEMISTRY, 2007, 68 (10) :1459-1463

[4]

Abe F, 1999, CHEM PHARM BULL, V47, P869

[5]

Pregnane glycosides from Caralluma russeliana [J].

Al-Yahya, MAA ;

Abdel-Sattar, E ;

Guittet, E .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (10) :1451-1453

[6]

The fall and rise of sleeping sickness [J].

Barrett, MP .

LANCET, 1999, 353 (9159) :1113-1114

[7]

New pregnane glycosides from Caralluma negevensis [J].

Braca, A ;

Bader, A ;

Morelli, I ;

Scarpato, R ;

Turchi, G ;

Pizza, C ;

De Tommasi, N .

TETRAHEDRON, 2002, 58 (29) :5837-5848

[8]

Camacho CM., 2000, Curr Opin Anti-Infect Invest Drugs, V2, P47

[9]

The relation between funding by the National Institutes of Health and the burden of disease [J].

Gross, CP ;

Anderson, GF ;

Rowe, NR .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (24) :1881-1887

[10]

Pregnane glycosides from Caralluma retrospiciens [J].

Halim, AF ;

Khalil, AT .

PHYTOCHEMISTRY, 1996, 42 (04) :1135-1139

← 1 2 3 →