Nigellidine-4-O-sulfite, the first sulfated indazole-type alkaloid from the seeds of Nigella sativa

被引：66

作者：

Ali, Zulfiqar ^{[1
]}

Ferreira, Daneel ^{[2
]}

Carvalho, Paulo ^{[3
]}

Avery, Mitchell A. ^{[3
]}

Khan, Ikhlas A. ^{[1
,2
]}

机构：

[1] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, Pharmaceut Sci Res Inst, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, Pharmaceut Sci Res Inst, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Dept Med Chem, Pharmaceut Sci Res Inst, University, MS 38677 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 06期

关键词：

D O I：

10.1021/np800172x

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The rare indazole-type alkaloid nigellidine (2) is accompanied by its 4-0-sulfite (4) in the seeds of Nigella sativa. Compound 4 may represent the true natural product leading to nigellidine (2) via hydrolysis of the sulfate functionality during the isolation process. The structure of nigellidine-4-0-sulfite (4) is confirmed by NMR, MS, and X-ray crystallographic data. This is the first report of the natural occurrence of sulfated indazole-type alkaloids.

引用

页码：1111 / 1112

页数：2

共 11 条

[1]

Herbal medicine in Jordan with special emphasis on commonly used herbs [J].