Nigellidine-4-O-sulfite, the first sulfated indazole-type alkaloid from the seeds of Nigella sativa

被引:66
作者
Ali, Zulfiqar [1 ]
Ferreira, Daneel [2 ]
Carvalho, Paulo [3 ]
Avery, Mitchell A. [3 ]
Khan, Ikhlas A. [1 ,2 ]
机构
[1] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, Pharmaceut Sci Res Inst, University, MS 38677 USA
[2] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, Pharmaceut Sci Res Inst, University, MS 38677 USA
[3] Univ Mississippi, Sch Pharm, Dept Med Chem, Pharmaceut Sci Res Inst, University, MS 38677 USA
来源
JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 06期
关键词
D O I
10.1021/np800172x
中图分类号
Q94 [植物学];
学科分类号
071001 [植物学];
摘要
The rare indazole-type alkaloid nigellidine (2) is accompanied by its 4-0-sulfite (4) in the seeds of Nigella sativa. Compound 4 may represent the true natural product leading to nigellidine (2) via hydrolysis of the sulfate functionality during the isolation process. The structure of nigellidine-4-0-sulfite (4) is confirmed by NMR, MS, and X-ray crystallographic data. This is the first report of the natural occurrence of sulfated indazole-type alkaloids.
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收藏
页码:1111 / 1112
页数:2
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