Endogenous proliferation: Burst-like CD4 T cell proliferation in lymphopenic settings

被引：39

作者：

Min, B ^{[1
]}

Paul, WE ^{[1
]}

机构：

[1] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA

来源：

SEMINARS IN IMMUNOLOGY | 2005年 / 17卷 / 03期

关键词：

CD4 T cells; endogenous proliferation; homeostasis; lymphopenia;

D O I：

10.1016/j.smim.2005.02.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rapid and slow proliferation is observed when naive CD4 T cells are transferred into lymphopenic hosts. We have recently proposed that the rapid, burst-like proliferation, designated endogenous proliferation, is a peripheral mechanism by which memory T cells of diverse specificity are generated without exogenous antigenic stimulation. In this review, we discuss some of unique features of endogenous proliferation. We argue that it is regulated not by the absolute number of memory cells present but by the range of specificities of those cells. We discuss the physiologic significance of endogenous proliferation and outline goals for future studies. Published by Elsevier Ltd.

引用

收藏

页码：201 / 207

页数：7

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