Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia

被引：105

作者：

Liu, D

Wu, LJ

Breyer, R

Mattson, MP

Andreasson, K

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[3] NIA, Gerontol Res Ctr, Neurosci Lab, Baltimore, MD 21224 USA

[4] Vanderbilt Univ, Sch Med, Dept Med, Div Nephrol, Nashville, TN 37212 USA

来源：

ANNALS OF NEUROLOGY | 2005年 / 57卷 / 05期

关键词：

D O I：

10.1002/ana.20461

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recent studies suggest a neuroprotective function of the PGE(2) EP2 receptor in excitotoxic neuronal injury. The function of the EP2 receptor was examined at time points after excitotoxicity in an organotypic hippocampal model of N-methyl-D-aspartate (NMDA) challenge and in a permanent model of focal forebrain ischemia. Activation of EP2 led to significant neuroprotection in hippocampal slices up to 3 hours after a toxic NMDA stimulus. Genetic deletion of EP2 resulted in a marked increase in stroke volume in the permanent middle cerebral artery occlusion model. These findings support further investigation into therapeutic strategies targeting the EP2 receptor in stroke.

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页码：758 / 761

页数：4

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