Why do T cells express the vitamin D receptor?

被引：53

作者：

Cantorna, Margherita T. ^{[1
]}

机构：

[1] Penn State Univ, Dept Vet & Biomed Sci, Ctr Mol Immunol & Infect Dis, University Pk, PA 16802 USA

来源：

YEAR IN IMMUNOLOGY | 2011年 / 1217卷

关键词：

vitamin D receptor; T cells; agonist selection; autoimmunity; 1,25-DIHYDROXYVITAMIN D-3; MULTIPLE-SCLEROSIS; IN-VITRO; INHIBITION; ACTIVATION; INTERLEUKIN-2; AUTOIMMUNITY; LYMPHOCYTES; DISEASE; TARGETS;

D O I：

10.1111/j.1749-6632.2010.05823.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vitamin D is an important regulator of immune function. T cells express the vitamin D receptor (VDR) and have been shown to be direct and indirect vitamin D targets. Why should T cells be responsive to vitamin D? The data suggest that expression of the VDR is required for the development of two cell types, NKT cells and CD8 alpha alpha T cells, which inhibit autoimmunity. In addition, effector T cell cytokine production is regulated by vitamin D. Available evidence suggests that NKT and CD8 alpha alpha T cells express the VDR as part of the selection process to protect against the generation of autoimmunity, particularly in the gut.

引用

页码：77 / 82

页数：6

共 44 条

[41] Expression of 1,25-dihydroxyvitamin D3 receptor in the immune system [J].

Veldman, CM ;

Cantorna, MT ;

DeLuca, HF .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2000, 374 (02) :334-338

[42] Helminths and the IBD Hygiene Hypothesis [J].

Weinstock, Joel V. ;

Elliott, David E. .

INFLAMMATORY BOWEL DISEASES, 2009, 15 (01) :128-133

[43] The vitamin D receptor is required for iNKT cell development [J].

Yu, Sanhong ;

Cantorna, Margherita T. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (13) :5207-5212

[44] Failure of T cell homing, reduced CD4/CD8αα intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice [J].

Yu, Sanhong ;

Bruce, Danny ;

Froicu, Monica ;

Weaver, Veronika ;

Cantorna, Margherita T. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (52) :20834-20839

← 1 2 3 4 5 →