Malaria: immune evasion by parasites

被引：62

作者：

Hisaeda, H

Yasutomo, K

Himeno, K

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Parasitol, Higashi Ku, Fukuoka 8128582, Japan

[2] Univ Tokushima, Inst Hlth Biosci, Dept Immunol & Parasitol, Grad Sch, Tokushima 7708503, Japan

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2005年 / 37卷 / 04期

关键词：

malaria; immune evasion; regulatory T cells;

D O I：

10.1016/j.biocel.2004.10.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Malaria is one of the most life-threatening infectious diseases worldwide. Specific immunity to natural infection is acquired slowly despite a high degree of repeated exposure and rarely continues for a long time even in endemic areas. Malaria parasites have evolved to acquire diverse immune evasion mechanisms that evoke poor immune responses and allow infection of individuals previously exposed. The shrewd schema of malaria parasites also hampers the development of effective vaccines. Furthermore, some of those mechanisms are essential for malaria pathogenesis. In this article, an outline of protective immunity to malaria is given, then strategies used by malaria parasites to evade host immunity, including antigen diversity/polymorphism, antigen variation and total immune suppression, are reviewed. Finally, trials to control malaria based on accumulating insights into the host-parasite relationship are discussed. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：700 / 706

页数：7

共 21 条

[1] Immunization of Aotus monkeys with a functional domain of the Plasmodium falciparum variant antigen induces protection against a lethal parasite line [J].