Antibodies to variable Plasmodium falciparum-infected erythrocyte surface antigens are associated with protection from novel malaria infections

被引:104
作者
Giha, HA
Staalsoe, T
Dodoo, D
Roper, C
Satti, GMH
Arnot, DE
Hviid, L
Theander, TG
机构
[1] Copenhagen Univ Hosp, Rigshosp, Dept Infect Dis, Ctr Med Parasitol, DK-2200 Copenhagen N, Denmark
[2] Univ Copenhagen, Inst Med Microbiol & Immunol, DK-2200 Copenhagen, Denmark
[3] Univ Khartoum, Fac Med, Dept Biochem, Khartoum, Sudan
[4] Noguchi Mem Inst Med Res, Immunol Unit, Legon, Ghana
[5] Univ Edinburgh, Inst Cell Anim & Populat Biol, Edinburgh, Midlothian, Scotland
基金
英国惠康基金;
关键词
Plasmodium falciparum-infected erythrocytes; malaria; variant antigens; Sudan;
D O I
10.1016/S0165-2478(99)00173-X
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In areas of unstable transmission malaria affects all age groups, but the malaria incidence is lower in adults compared to children and teenagers. Under such conditions subclinical Plasmodium falciparum infections are common and some infections are controlled, because blood parasitaemia is maintained at low densities. Here, we test the hypothesis that the presence or absence of antibodies against variant antigens on the surface of P. falciparum-infected erythrocytes protect individuals against some infectious challenges and render them susceptible to others. Plasma collected in Daraweesh, eastern Sudan, before and after the malaria season from individuals who had (susceptible) or did not have malaria (protected) during the season, were tested for reactivity against variant antigens on the surface of nine parasite isolates by flow cytometry. Both protected and susceptible individuals acquired antibodies to variant antigens during the malaria season. The presence of antibody to a Ghanaian isolate before the season was statistically significantly associated with protection against malaria. When considering all nine isolates, the patterns of antibody acquisition differed between susceptible and protected individuals. Together, the results indicate that pre-existing anti-PfEMP1 antibodies can reduce the risk of contracting clinical malaria when challenged by novel parasite clones expressing homologous, but not heterologous variable surface antigens. The results also confirm that antibodies to variant antigens are induced by both clinical and subclinical infections, and that antibodies against several var sere-types are induced during an infection. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:117 / 126
页数:10
相关论文
共 30 条
  • [1] Meeting at Manson House, London, 11 December 1997:: Unstable malaria in the Sudan:: the influence of the dry season -: Clone multiplicity of Plasmodium falciparum infections in individuals exposed to variable levels of disease transmission
    Arnot, D
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1998, 92 (06) : 580 - 585
  • [2] HOST AGE AS A DETERMINANT OF NATURALLY ACQUIRED-IMMUNITY TO PLASMODIUM-FALCIPARUM
    BAIRD, JK
    [J]. PARASITOLOGY TODAY, 1995, 11 (03): : 105 - 111
  • [3] Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria
    Bull, PC
    Lowe, BS
    Kortok, M
    Molyneux, CS
    Newbold, CI
    Marsh, K
    [J]. NATURE MEDICINE, 1998, 4 (03) : 358 - 360
  • [4] stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens
    Cheng, Q
    Cloonan, N
    Fischer, K
    Thompson, J
    Waine, G
    Lanzer, M
    Saul, A
    [J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1998, 97 (1-2) : 161 - 176
  • [5] An alternative to serum for cultivation of Plasmodium falciparum in vitro
    Cranmer, SL
    Magowan, C
    Liang, J
    Coppel, RL
    Cooke, BM
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1997, 91 (03) : 363 - 365
  • [6] PARASITE SEQUESTRATION IN PLASMODIUM-FALCIPARUM MALARIA - SPLEEN AND ANTIBODY MODULATION OF CYTOADHERENCE OF INFECTED ERYTHROCYTES
    DAVID, PH
    HOMMEL, M
    MILLER, LH
    UDEINYA, IJ
    OLIGINO, LD
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (16): : 5075 - 5079
  • [7] A hypothesis about the chronicity of malaria infection
    Druilhe, P
    Perignon, JL
    [J]. PARASITOLOGY TODAY, 1997, 13 (09): : 353 - 357
  • [8] HIGH PROPORTION OF SUBCLINICAL PLASMODIUM-FALCIPARUM INFECTIONS IN AN AREA OF SEASONAL AND UNSTABLE MALARIA IN SUDAN
    ELHASSAN, IM
    HVIID, L
    JAKOBSEN, PH
    GIHA, H
    SATTI, GMH
    ARNOT, DE
    JENSEN, JB
    THEANDER, TG
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1995, 53 (01) : 78 - 83
  • [9] DIVERSITY OF ANTIGENS EXPRESSED ON THE SURFACE OF ERYTHROCYTES INFECTED WITH MATURE PLASMODIUM-FALCIPARUM PARASITES IN PAPUA-NEW-GUINEA
    FORSYTH, KP
    PHILIP, G
    SMITH, T
    KUM, E
    SOUTHWELL, B
    BROWN, GV
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1989, 41 (03) : 259 - 265
  • [10] Variant antigens and endothelial receptor adhesion in Plasmodium falciparum
    Gardner, JP
    Pinches, RA
    Roberts, DJ
    Newbold, CI
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (08) : 3503 - 3508