Testicular FasL is expressed by sperm cells

被引：106

作者：

D'Alessio, A

Riccioli, A

Lauretti, P

Padula, F

Muciaccia, B

De Cesaris, P

Filippini, A

Nagata, S

Ziparo, E

机构：

[1] Univ Rome La Sapienza, Dept Histol & Med Embryol, Ist Pasteur, Fdn Cenci Bolognetti, I-00161 Rome, Italy

[2] Univ Aquila, Dept Expt Med, I-67100 Laquila, Italy

[3] Osaka Med Sch, Dept Genet, Suita, Osaka 565, Japan

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2001年 / 98卷 / 06期

关键词：

testis; immunoprivilege; fertility;

D O I：

10.1073/pnas.051566098

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The testis is the main source of Fas ligand (FasL) mRNA in rodents; it is generally believed that this molecule, expressed on bordering somatic Sertoli cells, bestows an immune-privileged status in the testis by eliminating infiltrating inflammatory Fas-bearing leukocytes. Our results demonstrate that the attribution of testicular expression of FasL to Sertoli cells is erroneous and that Fast transcription instead occurs in meiotic and postmeiotic germ cells, whereas the protein is only displayed on mature spermatozoa. These findings point to a significant role of the Fas system in the biology of mammalian reproduction.

引用

页码：3316 / 3321

页数：6

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