Total synthesis of the cyclopeptide alkaloid sanjoinine G1 and its C-11 epimer

被引：38

作者：

East, SP ^{[1
]}

Shao, F ^{[1
]}

Williams, L ^{[1
]}

Joullie, MM ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

来源：

TETRAHEDRON | 1998年 / 54卷 / 44期

关键词：

alkaloids; macrocycles; strained compounds;

D O I：

10.1016/S0040-4020(98)00808-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The naturally occurring cyclopeptide alkaloid sanjoinine G1 and its C-11 epimer were synthesized in 18 steps from D-serine. The key steps in the synthesis were the formation of the alkylaryl ether linkage via all SNAr reaction with 4-fluorobenzonitrile and the macrocyclization to form the 14-membered ring using a modification of the Schmidt protocol involving an activated pentafluorophenyl ester. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：13371 / 13390

页数：20

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