The catalytic asymmetric strecker reaction: Ketimines continue to join the fold

被引：123

作者：

Connon, Stephen J. ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Sch Chem, Ctr Synth & Chem Biol, Dublin, Ireland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 07期

关键词：

asymmetric synthesis; cyanides homogeneous; catalysis; ketimines; Strecker reaction;

D O I：

10.1002/anie.200703879

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Picking up the gauntlet: The challenge of developing highly effective catalyst systems for the enantioselective Strecker reaction to convert ketimine substrates (see scheme, red; A denotes protecting group) into a-amino nitriles (blue) and ultimately a-amino acids has been met by several recent developments. (Chemical Equation Presented) © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1176 / 1178

页数：3

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