Development of a novel neodymium compound for in vivo fluorescence imaging

被引:14
作者
Aita, Kazuki [1 ]
Temma, Takashi [1 ]
Kuge, Yuji [1 ]
Saji, Hideo [1 ]
机构
[1] Kyoto Univ, Dept Pathofunct Bioanal, Grad Sch Pharmaceut Sci, Kyoto, Japan
关键词
neodymium; near-infrared; fluorescein; energy transfer; long-lived luminescence;
D O I
10.1002/bio.984
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
We developed a novel fluorescent probe that contains the neodymium(III) complex moiety and fluorescein moiety. This probe can emit long-lived near-infrared luminescence derived from a Nd ion through excitation of the fluorescein moiety with visible light (lambda(ex) = 488 nm, lambda(em) = 880 nm, lifetime = 2.3 mu s). These results indicate the possibility of the probe as a candidate for in vivo fluorescence molecular imaging. Copyright (C) 2007 John Wiley & Sons, Ltd.
引用
收藏
页码:455 / 461
页数:7
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