Different Innate Signatures Induced in Human Monocyte-derived Dendritic Cells by Wild-Type Dengue 3 Virus, Attenuated but Reactogenic Dengue 3 Vaccine Virus, or Attenuated Nonreactogenic Dengue 1-4 Vaccine Virus Strains

被引：29

作者：

Balas, Claire ^{[1
]}

Kennel, Audrey ^{[1
]}

Deauvieau, Florence ^{[1
]}

Sodoyer, Regis ^{[1
]}

Arnaud-Barbe, Nadege ^{[1
]}

Lang, Jean ^{[1
]}

Guy, Bruno ^{[1
]}

机构：

[1] Sanofi Pasteur, Res & Dev, F-69280 Marcy Letoile, France

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 203卷 / 01期

关键词：

GENE-EXPRESSION; INTERFERON; INFECTION; ACTIVATION; SEROTYPES;

D O I：

10.1093/infdis/jiq022

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

DNA microarrays were used to assess the innate gene signature in human myeloid dendritic cells infected with chimeric dengue 1-4 vaccines, a wild-type dengue 3 virus, or a classically attenuated serotype 3 vaccine shown to be reactogenic in humans. We observed a very reproducible signature for each of the 4 chimeric dengue vaccines, involving stimulation of type I interferon and associated genes, together with genes encoding chemokines and other mediators involved in the initiation of adaptive responses. In contrast, wild-typeDEN3 virus induced a predominantly inflammatory profile, while the reactogenic attenuated serotype 3 vaccine appeared to induce a blunted response.

引用

页码：103 / 108

页数：6

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