Structural biology of cadherins in the nervous system

被引：34

作者：

Shapiro, L ^{[1
]}

Colman, DR

机构：

[1] Mt Sinai Sch Med, Dept Physiol & Biophys, Struct Biol Program, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Brookdale Ctr Dev & Mol Biol, New York, NY 10029 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1998年 / 8卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-4388(98)80086-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The complex functions of the nervous system reflect the coordinated action of intricately connected networks of neurons. Recent work has combined to suggest the importance of the cadherin family of cell adhesion molecules in specifying these connections at neural synapses. High-resolution structural studies and site-directed mutagenesis have revealed some of the molecular mechanisms by which cadherins function in cell-to-cell adhesion, and suggest new avenues for investigation.

引用

页码：593 / 599

页数：7

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