MicroRNA regulation of neural plasticity and memory

被引：125

作者：

Bredy, Timothy W. ^{[1
]}

Lin, Quan ^{[2
]}

Wei, Wei ^{[1
]}

Baker-Andresen, Danay ^{[1
]}

Mattick, John S. ^{[3
]}

机构：

[1] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia

[2] Univ Calif Los Angeles, Semel Inst Neurosci, Los Angeles, CA 90291 USA

[3] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2011年 / 96卷 / 01期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

Epigenetic; MicroRNA; Learning; Memory; CAENORHABDITIS-ELEGANS; PROTEIN-SYNTHESIS; BRAIN-DEVELOPMENT; NEURONAL-ACTIVITY; NONCODING RNAS; NUCLEAR EXPORT; MESSENGER-RNAS; COCAINE INTAKE; HUMAN GENOME; C-ELEGANS;

D O I：

10.1016/j.nlm.2011.04.004

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

MicroRNAs (miRNAs) are a class of endogenous, small non-coding RNAs that mediate post-transcriptional gene silencing by complementary binding to the 3'untranslated region of target mRNAs. The transient and localized expression of these small RNAs in dendrites, their capacity to respond in an activity-dependent manner, and the observation that a single miRNA can simultaneously regulate many genes, make brain-specific miRNAs ideal candidates for the fine-tuning of gene expression associated with neural plasticity and memory formation. Here we provide an overview of the current literature, which supports the proposal that non-coding RNA-mediated regulation of gene function represents an important, yet underappreciated, layer of epigenetic control that contributes to learning and memory in the adult brain. (c) 2011 Elsevier Inc. All rights reserved.

引用

页码：89 / 94

页数：6

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