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Repopulation of cancer cells during therapy: An important cause of treatment failure

被引：534
作者：
Kim, JJ
Tannock, IF
机构：
[1] Princess Margaret Hosp, Dept Med Oncol, Toronto, ON M5G 2M9, Canada
[2] Univ Toronto, Toronto, ON M5G 2M9, Canada
[3] Princess Margaret Hosp, Dept Radiat Oncol, Toronto, ON M5G 2M9, Canada
来源：
NATURE REVIEWS CANCER | 2005年 / 5卷 / 07期
关键词：
D O I：
10.1038/nrc1650
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Radiotherapy and chemotherapy are given in multiple doses, which are spaced out to allow the recovery of normal tissues between treatments. However, surviving cancer cells also proliferate during the intervals between treatments and this process of repopulation is an important cause of treatment failure. Strategies developed to overcome repopulation have improved clinical outcomes, and now new strategies to inhibit repopulation are emerging in parallel with advances in the understanding of underlying biological mechanisms.
引用
收藏
页码：516 / 525
页数：10
相关论文
共 102 条
  • [1] Akimoto T, 1999, CLIN CANCER RES, V5, P2884
  • [2] THE EFFECT OF THE OVERALL TREATMENT TIME OF FRACTIONATED-IRRADIATION ON THE TUMOR-CONTROL PROBABILITY OF A HUMAN SOFT-TISSUE SARCOMA XENOGRAFT IN NUDE-MICE
    ALLAM, A
    PEREZ, LA
    HUANG, PG
    TAGHIAN, A
    AZINOVIC, I
    FREEMAN, J
    DUFFY, M
    EFIRD, J
    SUIT, HD
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1995, 32 (01): : 105 - 111
  • [3] Ang KK, 2002, CANCER RES, V62, P7350
  • [4] The effect of ionizing radiation on signal transduction: Antibodies to EGF receptor sensitize A431 cells to radiation
    Balaban, N
    Moni, J
    Shannon, M
    Dang, LO
    Murphy, E
    Goldkorn, T
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1996, 1314 (1-2): : 147 - 156
  • [5] Accelerated versus standard cyclophosphamide, epirubicin and 5-fluorouracil or cyclophosphamide, methotrexate and 5-fluorouracil: a randomized phase III trial in locally advanced breast cancer
    Baldini, E
    Gardin, G
    Giannessi, PG
    Evangelista, G
    Roncella, M
    Prochilo, T
    Collecchi, P
    Rosso, R
    Lionetto, R
    Bruzzi, P
    Mosca, F
    Conte, PF
    [J]. ANNALS OF ONCOLOGY, 2003, 14 (02) : 227 - 232
  • [6] THE EFFECT OF TREATMENT TIME AND TREATMENT INTERRUPTION ON TUMOR-CONTROL FOLLOWING RADICAL RADIOTHERAPY OF LARYNGEAL-CANCER
    BARTON, MB
    KEANE, TJ
    GADALLA, T
    MAKI, E
    [J]. RADIOTHERAPY AND ONCOLOGY, 1992, 23 (03) : 137 - 143
  • [7] SHOULD TUMORS BE CLAMPED IN RADIOBIOLOGICAL FRACTIONATION EXPERIMENTS
    BECKBORNHOLDT, HP
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1991, 21 (03): : 675 - 682
  • [8] INFLUENCE OF TREATMENT TIME ON THE RESPONSE OF RAT RHABDOMYOSARCOMA R1H TO FRACTIONATED-IRRADIATION
    BECKBORNHOLDT, HP
    OMNICZYNSKI, M
    THEIS, E
    VOGLER, H
    WURSCHMIDT, F
    [J]. ACTA ONCOLOGICA, 1991, 30 (01) : 57 - 63
  • [9] THE PREDICTIVE VALUE OF CELL KINETIC MEASUREMENTS IN A EUROPEAN TRIAL OF ACCELERATED FRACTIONATION IN ADVANCED HEAD AND NECK TUMORS - AN INTERIM-REPORT
    BEGG, AC
    HOFLAND, I
    MOONEN, L
    BARTELINK, H
    SCHRAUB, S
    BONTEMPS, P
    LEFUR, R
    VANDENBOGAERT, W
    CASPERS, R
    VANGLABBEKE, M
    HORIOT, JC
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1990, 19 (06): : 1449 - 1453
  • [10] TUMOR-CELL REPOPULATION DURING FRACTIONATED RADIOTHERAPY - CORRELATION BETWEEN FLOW CYTOMETRIC AND RADIOBIOLOGICAL DATA IN 3 MURINE TUMORS
    BEGG, AC
    HOFLAND, I
    KUMMERMEHR, J
    [J]. EUROPEAN JOURNAL OF CANCER, 1991, 27 (05) : 537 - 543
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