Repopulation of cancer cells during therapy: An important cause of treatment failure

被引：534

作者：

Kim, JJ

Tannock, IF

机构：

[1] Princess Margaret Hosp, Dept Med Oncol, Toronto, ON M5G 2M9, Canada

[2] Univ Toronto, Toronto, ON M5G 2M9, Canada

[3] Princess Margaret Hosp, Dept Radiat Oncol, Toronto, ON M5G 2M9, Canada

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 07期

关键词：

D O I：

10.1038/nrc1650

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radiotherapy and chemotherapy are given in multiple doses, which are spaced out to allow the recovery of normal tissues between treatments. However, surviving cancer cells also proliferate during the intervals between treatments and this process of repopulation is an important cause of treatment failure. Strategies developed to overcome repopulation have improved clinical outcomes, and now new strategies to inhibit repopulation are emerging in parallel with advances in the understanding of underlying biological mechanisms.

引用

收藏

页码：516 / 525

页数：10

相关论文

共 102 条

[61] Applying radiobiological principles to combined modality treatment of head and neck cancer - The time factor [J].

Peters, LJ ;

Withers, HR .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1997, 39 (04) :831-836

[62] Proliferation and micromilieu during fractionated irradiation of human FaDu squamous cell carcinoma in nude mice [J].

Petersen, C ;

Eicheler, W ;

Frömmel, A ;

Krause, M ;

Balschukat, S ;

Zips, D ;

Baumann, M .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2003, 79 (07) :469-477

[63] Repopulation of FaDu human squamous cell carcinoma during fractionated radiotherapy correlates with reoxygenation [J].

Petersen, C ;

Zips, D ;

Krause, M ;

Schöne, K ;

Eicheler, W ;

Hoinkis, C ;

Thames, HD ;

Baumann, M .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2001, 51 (02) :483-493

[64] Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of elderly patients with aggressive lymphomas:: results of the NHL-B2 trial of the DSHNHL [J].

Pfreundschuh, M ;

Trümper, L ;

Kloess, M ;

Schmits, R ;

Feller, AC ;

Rübe, C ;

Rudolph, C ;

Reiser, M ;

Hossfeld, DK ;

Eimermacher, H ;

Hasenclever, D ;

Schmitz, N ;

Loeffler, M .

BLOOD, 2004, 104 (03) :634-641

[65] A randomised trial of accelerated and conventional radiotherapy for stage III and IV squamous carcinoma of the head and neck: a Trans-Tasman Radiation Oncology Group Study [J].

Poulsen, MG ;

Denham, JW ;

Peters, LJ ;

Lamb, DS ;

Spry, NA ;

Hindley, A ;

Krawitz, H ;

Hamilton, C ;

Keller, J ;

Tripcony, L ;

Walker, Q .

RADIOTHERAPY AND ONCOLOGY, 2001, 60 (02) :113-122

[66] Influence of dose per fraction and overall treatment time on the response of pulmonary micrometastases of the R1H-tumour to fractionated irradiation [J].

Raabe, A ;

Eickhölter, S ;

Zieron, J ;

Krüll, A ;

Beck-Bornholdt, HP ;

Alberti, W .

RADIOTHERAPY AND ONCOLOGY, 2000, 56 (02) :259-264

[67] Tirapazamine, cisplatin, and radiation versus fluorouracil, cisplatin, and radiation in patients with locally advanced head and neck cancer: A randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02) [J].

Rischin, D ;

Peters, L ;

Fisher, R ;

Macann, A ;

Denham, J ;

Poulsen, M ;

Jackson, M ;

Kenny, L ;

Penniment, M ;

Corry, J ;

Lamb, D ;

McClure, B .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (01) :79-87

[68] REPOPULATION BETWEEN RADIATION FRACTIONS IN HUMAN-MELANOMA XENOGRAFTS [J].

ROFSTAD, EK .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1992, 23 (01) :63-68

[69]

ROSENBLUM ML, 1976, CANCER RES, V36, P3718

[70] IMPROVED TREATMENT OF A BRAIN-TUMOR MODEL .1. ADVANTAGES OF SINGLE-DOSE OVER MULTIPLE-DOSE BCNU SCHEDULES [J].

ROSENBLUM, ML ;

GEROSA, MA ;

DOUGHERTY, DV ;

WILSON, CB .

JOURNAL OF NEUROSURGERY, 1983, 58 (02) :177-182

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