Staudinger ligation:: A new immobilization strategy for the preparation of small-molecule arrays

被引：153

作者：

Köhn, M

Wacker, R

Peters, C

Schröder, H

Soulère, L

Breinbauer, R

Niemeyer, CM

Waldmann, H

机构：

[1] Max Planck Inst Mol Physiol, Dept Chem Biol, D-44227 Dortmund, Germany

[2] Univ Dortmund, Fachbereich Chem Organ Chem, D-44227 Dortmund, Germany

[3] Chimera Biotec GmbH, D-44227 Dortmund, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 47期

关键词：

bioorganic chemistry; combinatorial chemistry; microarrays; solid-phase synthesis; Staudinger ligation;

D O I：

10.1002/anie.200352877

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chemoselective coupling: The Staudinger ligation between azide-functionalized small molecules and a phosphane-modified glass surface offers a new immobilization strategy for the preparation of drug arrays through the formation of a thermodynamically stable amide (see scheme).

引用

页码：5830 / 5834

页数：5

共 40 条

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