The generation of antigenic peptides bound and presented to the immune system by MHC class I molecules predominantly depends on the function of the proteasome system. Stimulation of cells with interferon gamma induces the incorporation of three active site bearing beta-subunits into the 20S proteasome and the formation of the PA28 proteasome modulator complex. PA28 alters the cleavage properties of the proteasome and enhances MHC class I antigen presentation. Thus, by cytokine induced change of the proteasome system cells may alter the proteolytic properties of the 20S proteasome and may render an organism more flexible in its peptide generation capacity.
机构:
Scripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USAScripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USA
Ahn, K
;
Erlander, M
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USAScripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USA
Erlander, M
;
Leturcq, D
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USAScripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USA
Leturcq, D
;
Peterson, PA
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USAScripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USA
Peterson, PA
;
Fruh, K
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USAScripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USA
Fruh, K
;
Yang, Y
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USAScripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USA
机构:
Scripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USAScripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USA
Ahn, K
;
Erlander, M
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USAScripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USA
Erlander, M
;
Leturcq, D
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USAScripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USA
Leturcq, D
;
Peterson, PA
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USAScripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USA
Peterson, PA
;
Fruh, K
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USAScripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USA
Fruh, K
;
Yang, Y
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USAScripps Res Inst, RW JOHNSON PHARMACEUT RES INST, DEPT IMMUNOL, IMM23, LA JOLLA, CA 92037 USA