The role of the proteasome system and the proteasome activator PA28 complex in the cellular immune response

被引:53
作者
Kloetzel, PM [1 ]
Soza, A [1 ]
Stohwasser, R [1 ]
机构
[1] Humboldt Univ, Inst Biochem Charite, D-10117 Berlin, Germany
关键词
antigen processing; PA28; proteasome;
D O I
10.1515/BC.1999.040
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The generation of antigenic peptides bound and presented to the immune system by MHC class I molecules predominantly depends on the function of the proteasome system. Stimulation of cells with interferon gamma induces the incorporation of three active site bearing beta-subunits into the 20S proteasome and the formation of the PA28 proteasome modulator complex. PA28 alters the cleavage properties of the proteasome and enhances MHC class I antigen presentation. Thus, by cytokine induced change of the proteasome system cells may alter the proteolytic properties of the 20S proteasome and may render an organism more flexible in its peptide generation capacity.
引用
收藏
页码:293 / 297
页数:5
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