Trypanosomicidal kaurane diterpenes from Wedelia paludosa

被引：46

作者：

Batista, R

Chiari, E

de Oliveira, AB

机构：

[1] Univ Fed Minas Gerais, Fac Farm, Dept Prod Farmaceut, BR-30180112 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Inst Ciencias Exatas, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Inst Ciencias Biol, Belo Horizonte, MG, Brazil

来源：

PLANTA MEDICA | 1999年 / 65卷 / 03期

关键词：

D O I：

10.1055/s-2006-960781

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The diterpenes ent-kaur-16-en-19-oic acid, ent-kaur-9(11),16(17)-dien-19-oic acid and 3 alpha-angeloiloxy-ent-kaur-16-en-19-oic acid were identified as trypanosomicidal compounds of the ethanolic extract from the aerial parts of Wedelia paludosa D.C. (Asteraceae), showing activity up to the lowest dose of 0.68 mg/mL in the in vitro assay against trypomastigotes of T. cruzi, the causative agent of Chagas' disease (American trypanosomiasis), The other isolates, friedelan-3 beta-ol, ent-kaur-16 alpha-ol-19-oic acid, beta-amyrin acetate and (22-E)-stigmasta-5,22-dien-3 beta-ol, were inactive. This is the first report on the trypano, somicidal activity of ent-kaur-9(11),16(17)-dien-19-oic acid and 3 alpha-angeloiloxy-ent-kaur-16-en-19-oic acids; this effect was already known for ent-kaur-16-en-19-oic acid.

引用

页码：283 / 284

页数：2

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