Hyperoxia-derived lung damage in preterm infants

被引：179

作者：

Bhandari, Vineet ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Pediat, Div Perinatal Med, New Haven, CT 06520 USA

来源：

SEMINARS IN FETAL & NEONATAL MEDICINE | 2010年 / 15卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Cell death; Cytokines; Oxidants; Oxygen; Pulmonary; KERATINOCYTE GROWTH-FACTOR; NEWBORN RAT LUNG; CELL-DEATH; TRANSFORMING GROWTH-FACTOR-BETA-1; GENE-EXPRESSION; INDUCED INJURY; ADULT MICE; TGF-BETA; BRONCHOPULMONARY; MODEL;

D O I：

10.1016/j.siny.2010.03.009

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

Hyperoxia-induced lung injury is characterized by an influx of inflammatory cells, increased pulmonary permeability, endothelial and epithelial cell death. This review highlights the mechanistic aspects of inflammation, vascular leak and cell death. The focus will be on agents that contribute to hyperoxia-induced lung injury in developmentally appropriate animal models, and those that have been detected in human premature neonates. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：223 / 229

页数：7

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