Pitfalls, Problems, and Progress in Bronchopulmonary Dysplasia

被引：189

作者：

Bhandari, Anita ^{[2
]}

Bhandari, Vineet ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Pediat, Div Perinatal Med, New Haven, CT 06520 USA

[2] Connecticut Childrens Med Ctr, Div Pediat Pulmonol, Hartford, CT USA

来源：

PEDIATRICS | 2009年 / 123卷 / 06期

关键词：

chronic lung disease; prematurity; pulmonary sequelae; noninvasive ventilation; CHRONIC LUNG-DISEASE; INHALED NITRIC-OXIDE; ENDOTHELIAL GROWTH-FACTOR; RESPIRATORY-DISTRESS-SYNDROME; POSITIVE-PRESSURE VENTILATION; RANDOMIZED CONTROLLED-TRIAL; INTENSIVE-CARE-UNIT; SOLUBLE E-SELECTIN; PRETERM INFANTS; PREMATURE-INFANTS;

D O I：

10.1542/peds.2008-1962

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Bronchopulmonary dysplasia is a chronic lung disease associated with premature birth and characterized by early lung injury. In this review we discuss some pitfalls, problems, and progress in this condition over the last decade, focusing mainly on the last 5 years, limited to studies in human neonates. Changes in the definition, pathogenesis, genetic susceptibility, and recent biomarkers associated with bronchopulmonary dysplasia will be discussed. Progress in current management strategies, along with novel approaches/therapies, will be critically appraised. Finally, recent data on long-term pulmonary and neurodevelopmental outcomes of infants with bronchopulmonary dysplasia will be summarized. Pediatrics 2009; 123: 1562-1573

引用

页码：1562 / 1573

页数：12

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