Trends in the evolution of the proopiomelanocortin gene

被引：62

作者：

Dores, RM ^{[1
]}

Lecaude, S ^{[1
]}

机构：

[1] Univ Denver, Dept Biol Sci, Denver, CO 80208 USA

来源：

GENERAL AND COMPARATIVE ENDOCRINOLOGY | 2005年 / 142卷 / 1-2期

关键词：

proopiomelanocortin; ACTH; alpha-MSH; beta-MSH; gamma-MSH; delta-MSH; beta-endorphin; agnatha; chondrichthyes; actinopterygii; sarcopterygii;

D O I：

10.1016/j.ygcen.2005.02.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The POMC gene is perhaps the most extensively Studied member of the opioid/orphanin gene family. In Phylum Chordata this gene has been characterized in representatives of every class within the Gnathostomata, as well as in one representative agnathan vertebrate, the marine lamprey. This review provides a systematic overview of trends in the evolution of the melanocortins (ACTH/alpha-MSH, beta-MSH, gamma-MSH, and delta-MSH) and beta-endorphin in gnathostomes, and advances the hypothesis that the appearance of gamma-MSH occurred early in the radiation of the gnathostomes. A summary of the extensive work on POMC genes in the marine lamprey is also provided, as well as a reevaluation of the conserved regions in the sequence of CLIP (corticotropin-like-intermediate lobe peptide) in the POMC sequences of the various groups of gnathostomes. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：81 / 93

页数：13

共 67 条

[51] ONE OF THE 2 TROUT PROOPIOMELANOCORTIN MESSENGER-RNAS POTENTIALLY ENCODES NEW PEPTIDES [J].