Materials for protein delivery in tissue engineering

被引:196
作者
Baldwin, SP [1 ]
Saltzman, WM [1 ]
机构
[1] Cornell Univ, Sch Chem Engn, Ithaca, NY 14853 USA
基金
美国国家航空航天局; 美国国家科学基金会; 美国国家卫生研究院;
关键词
drug delivery; growth factors; protein therapeutics; tissue engineering; polymers; controlled release;
D O I
10.1016/S0169-409X(98)00021-0
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The ability of protein agents to modulate cellular behaviors, such as motility, proliferation, adhesion and function, is the subject of intense research; new therapies involving proteins will likely result. Unfortunately, many proteins have short half-lives and the potential for toxicity after systemic delivery, so traditional routes of administration are not appropriate. Alternate methods for sustained delivery of these agents to the desired cells and tissues in biologically active conformations and concentrations are necessary. Techniques similar to those long used in the controlled delivery of drugs have been used to administer certain growth factors to cells and tissues; although clinical success has been limited to date, studies in animal models suggest the potential for tremendous advances in the near future. This review outlines the basic technology of controlled protein delivery using polymeric materials, and discusses some of the techniques under investigation for the efficient administration of proteins in tissue engineering. (C) 1998 Elsevier Science BN. All rights reserved.
引用
收藏
页码:71 / 86
页数:16
相关论文
共 98 条
  • [1] ALBERTS B, 1994, MOL BIOL CELL, P1294
  • [2] AXELSSON B, 1988, J IMMUNOL, V141, P2912
  • [3] BELCHEVA N, IN PRESS J BIOMATER
  • [4] GLUCOSE-CONTROLLED INSULIN-DELIVERY SYSTEM - SEMI-SYNTHETIC INSULIN BOUND TO LECTIN
    BROWNLEE, M
    CERAMI, A
    [J]. SCIENCE, 1979, 206 (4423) : 1190 - 1191
  • [5] SUSTAINED-RELEASE OF NERVE GROWTH-FACTOR FROM BIODEGRADABLE POLYMER MICROSPHERES
    CAMARATA, PJ
    SURYANARAYANAN, R
    TURNER, DA
    PARKER, RG
    EBNER, TJ
    [J]. NEUROSURGERY, 1992, 30 (03) : 313 - 319
  • [6] BLENDS OF SYNTHETIC AND NATURAL POLYMERS AS DRUG-DELIVERY SYSTEMS FOR GROWTH-HORMONE
    CASCONE, MG
    SIM, B
    DOWNES, S
    [J]. BIOMATERIALS, 1995, 16 (07) : 569 - 574
  • [7] EFFECTS OF EPIDERMAL GROWTH-FACTOR DOSAGE FORMS ON DERMAL WOUND STRENGTH IN MICE
    CELEBI, N
    ERDEN, N
    GONUL, B
    KOZ, M
    [J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1994, 46 (05) : 386 - 387
  • [8] CHARETTE MF, 1997, PRINCIPLES TISSUE EN, P727
  • [9] CLELAND JL, 1995, P INT S CONTR REL BI, V22, P149
  • [10] Craig CG, 1996, J NEUROSCI, V16, P2649