Mimicking the biologically active part of the cyclopeptides segetalin A and B by "clipping" of a linear tripeptide derivative by metal coordination

被引：5

作者：

Albrecht, M

Stortz, P

Weis, P

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

[2] Univ Karlsruhe, Inst Chem Phys, D-76128 Karlsruhe, Germany

来源：

SUPRAMOLECULAR CHEMISTRY | 2003年 / 15卷 / 7-8期

关键词：

peptide coupling; cyclopeptide; coordination compound; segetalin;

D O I：

10.1080/10610270310001605070

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new method for the conformational fixation of bioactive loop-type peptide structures is presented. Hereby, ligand moieties are attached to the termini of a linear peptide sequence. Upon metal complexation, a macrocyclic structure with a loop-type conformation of the peptide is formed. As a representative example, the preparation of a WAG-bridged dicatechol derivative is described which mimics the active part of the natural products Segetalin A and Segetalin B.

引用

页码：477 / 483

页数：7

共 35 条

[1]

Albrecht M, 2002, SYNTHESIS-STUTTGART, P126

[2] The fixation of linear versus loop-type peptidic structures by metal coordination:: the coordination chemistry of Val-Val- and Val-Val-Val-bridged dicatechol ligands [J].