Talampanel

被引：61

作者：

Howes, John F.

Bell, Cynthia ^{[1
]}

机构：

[1] IVAX Res Inc, Dept New Drug Dev, Miami, FL 33137 USA

[2] IVAX Res Inc, Dept Oncol, Miami, FL 33137 USA

[3] IVAX Res Inc, Dept CNS, Miami, FL 33137 USA

来源：

NEUROTHERAPEUTICS | 2007年 / 4卷 / 01期

关键词：

AMPA; epilepsy; glutamate; neuroprotection; talampanel;

D O I：

10.1016/j.nurt.2006.11.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Talampanel is a novel anticonvulsant that acts as an allosteric inhibitor of the AMPA receptor. Talampanel has a broad spectrum of action in animal models of epilepsy and neuroprotection. Clinical experience to date has been able to show effectiveness in reduction of seizures in patients with refractory partial seizures.

引用

页码：126 / 129

页数：4

共 24 条

[21] Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655 [J].