Gypsophin:: A novel α-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana

被引：49

作者：

Luo, Jian-Guang ^{[1
]}

Wang, Xiao-Bing ^{[1
]}

Ma, Li ^{[1
]}

Kong, Ling-Yi ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 16期

基金：

中国国家自然科学基金;

关键词：

gypsophin; cyclic peptide; Gypsophila oldhamiana; caryophyllaceae; cystallographic data; alpha-glucosidase inhibitor;

D O I：

10.1016/j.bmcl.2007.06.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

An unusual new cyclic peptide with a pyrrolidine-2,5-dione unit, gypsophin (1), was isolated from Gypsophila oldhamiana. Its structure was elucidated by the spectroscopic evidences. The stereochemistry was determined by application of the Marfey's method and the single-crystal X-ray diffraction. Compound I exhibited inhibitory activity against, ot-glucosidase with IC50 Of 305 mu M. (c) 2007 Elsevier Ltd. All rights reserved.

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收藏

页码：4460 / 4463

页数：4

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