Sensitivity enhancement in photonic crystal slab biosensors

被引：159

作者：

El Beheiry, Mohamed ^{[1
]}

Liu, Victor ^{[2
]}

Fan, Shanhui ^{[2
]}

Levi, Ofer ^{[1
,3
]}

机构：

[1] Univ Toronto, Edward S Rogers Sr Dept Elect & Comp Engn, Toronto, ON M5S 3G4, Canada

[2] Stanford Univ, Dept Elect Engn, Stanford, CA 94305 USA

[3] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada

来源：

OPTICS EXPRESS | 2010年 / 18卷 / 22期

基金：

加拿大自然科学与工程研究理事会;

关键词：

SURFACE-PLASMON RESONANCE; LABEL-FREE DETECTION; MICROCAVITY SENSOR; QUANTUM DOTS; FLUORESCENCE; MATRIX; MODES;

D O I：

10.1364/OE.18.022702

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Refractive index sensitivity of guided resonances in photonic crystal slabs is analyzed. We show that modal properties of guided resonances strongly affect spectral sensitivity and quality factors, resulting in substantial enhancement of refractive index sensitivity. A three-fold spectral sensitivity enhancement is demonstrated for suspended slab designs, in contrast to designs with a slab resting over a substrate. Spectral sensitivity values are additionally shown to be unaffected by quality factor reductions, which are common to fabricated photonic crystal nanostructures. Finally, we determine that proper selection of photonic crystal slab design parameters permits biosensing of a wide range of analytes, including proteins, antigens, and cells. These photonic crystals are compatible with large-area biosensor designs, permitting direct access to externally incident optical beams in a microfluidic device. (C) 2010 Optical Society of America

引用

页码：22702 / 22714

页数：13

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