The role of radiotherapy in multimodal treatment of pancreatic carcinoma

被引：39

作者：

Brunner, Thomas B. ^{[1
]}

Scott-Brown, Martin ^{[1
]}

机构：

[1] Univ Oxford, Gray Inst Radiat Oncol & Biol, Oxford, England

来源：

RADIATION ONCOLOGY | 2010年 / 5卷

基金：

英国工程与自然科学研究理事会;

关键词：

COOPERATIVE-ONCOLOGY-GROUP; PHASE-III TRIAL; RANDOMIZED CONTROLLED-TRIAL; GEMCITABINE-BASED CHEMORADIATION; LOCALLY ADVANCED ADENOCARCINOMA; PREOPERATIVE RADIATION-THERAPY; NEOADJUVANT CHEMORADIATION; CONCURRENT RADIOTHERAPY; RESECTABLE ADENOCARCINOMA; 5-FLUOROURACIL INFUSION;

D O I：

10.1186/1748-717X-5-64

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic ductal carcinoma is one of the most lethal malignancies, but in recent years a number of positive developments have occurred in the management of pancreatic carcinoma. This article aims to give an overview of the current knowledge regarding the role of radiotherapy in the treatment of pancreatic ductal adenocarcinoma (PDAC). The results of meta-analyses, phase III-studies, and phase II-studies using chemoradiotherapy and chemotherapy for resectable and non-resectable PDAC were reviewed. The use of radiotherapy is discussed in the neoadjuvant and adjuvant settings as well as in the locally advanced situation. Whenever possible, radiotherapy should be performed as simultaneous chemoradiotherapy. Patients with PDAC should be offered entry into clinical trials to identify optimal treatment results.

引用

页数：12

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