Thermodynamic analysis of interactions between N-linked sugar chains and F-box protein Fbs1

被引：41

作者：

Hagihara, S

Totani, K

Matsuo, I

Ito, Y

机构：

[1] RIKEN, Inst Phys & Chem Res, Wako, Saitama 3510198, Japan

[2] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama 3321102, Japan

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2005年 / 48卷 / 09期

关键词：

D O I：

10.1021/jm0489511

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fbs1 is a recently discovered F-box protein that was proposed to recognize high-mannose-type asparagine-linked glycoprotein sugar chains. To reveal the specificity of Fbs1, Man alpha 1 -> 6Man beta 1 -> 4GlcNAc(2), Man alpha 1 -> 3Mar beta -> 4GlcNAc(2), and Man alpha 1 -> 3(Man alpha 1 -> 6)Man beta 1 -> 4GlcNAc(2) were synthesized and their affinities for Fbs1 were evaluated in comparison with previously synthesized Man(9)GlcNAc(2) and Man(8)GlcNAc(2). These analyses revealed that Man(3)GlcNAc(2) had the strongest affinity and the chitobiose and alpha 1 -> 6 linked Man residue are necessary for Fbs1 to recognize a sugar.

引用

收藏

页码：3126 / 3129

页数：4

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