Ergosterol peroxide from flowers of Erigeron annuus L. as an anti-atherosclerosis agent

被引：45

作者：

Kim, DH

Jung, SJ

Chung, IS

Lee, YH

Kim, DK

Kim, SH

Kwon, BM

Jeong, TS

Park, MH

Seoung, NS

Baek, NI ^{[1
]}

机构：

[1] Kyung Hee Univ, Grad Sch Biotechnol, Suwon 449701, South Korea

[2] Kyung Hee Univ, Plant Metab Res Ctr, Suwon 449701, South Korea

[3] Woosuk Univ, Dept Pharm, Jeunju 565701, South Korea

[4] Kyung Hee Univ, Grad Sch EW Med Sci, Suwon 449701, South Korea

[5] Korea Res Inst Biosci & Biotechnol, Taejon 305333, South Korea

[6] Erom Life Co Ltd, Seoul 135825, South Korea

[7] RDA, Natl Inst Crop Sci, Suwon 441857, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2005年 / 28卷 / 05期

关键词：

Erigeron annuus L; compositae; hACAT1 inhibitory effect; Lp-PLA(2) inhibitory effect; ergosterol peroxide;

D O I：

10.1007/BF02977755

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Flowers of Erigeron annuus L. were extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH, and H2O. Repeated silica gel and ODS column chromatography of the EtOAc fraction led to the isolation of a sterol, through activity-guided fractionation, using ACAT inhibitory activity measurements. From the physico-chemical data, including NMR, MS, and IR, the chemical structure of the compound was determined to be an ergosterol peroxide (1), which has been isolated for the first time from this plant. This compound exhibited hACAT-1 and Lp-PLA(2) inhibitory effects, with inhibitory values of 51.6 +/- 0.9 and 51.7 +/- 1.2%, at a treatment concentration of 0.23 mM.

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收藏

页码：541 / 545

页数：5

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