Synthesis of the extracellular Ig domain I of Emmprin carrying a chitobiose unit

被引：29

作者：

Hojo, H ^{[1
]}

Watabe, J

Nakahara, Y

Ito, Y

Nabeshima, K

Toole, BP

机构：

[1] Tokai Univ, Dept Ind Chem, Hiratsuka, Kanagawa 2591292, Japan

[2] RIKEN, Inst Phys & Chem Res, Wako, Saitama 3510198, Japan

[3] Miyazaki Med Coll, Dept Pathol, Miyazaki 8891692, Japan

[4] Tufts Univ, Sch Med, Dept Anat & Cellular Biol, Boston, MA 02111 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 16期

关键词：

thioesters; glycopeptides; condensations;

D O I：

10.1016/S0040-4039(01)00342-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The extracellular Ig domain I of Emmprin (34-94) carrying a chitobiose unit at Asn(44) was chemically synthesized. Boc-Asn with a benzyl-protected chitobiose unit was synthesized and used for the preparation of peptide thioester with the sequence of Emmprin (34-58) by Boc strategy. C-Terminal peptide amide (59-94) was also prepared by the solid-phase method. These segments were condensed by activation of the thioester group by silver ions to obtain a protected form of Emmprin (34-94)-NH2. After deprotection and air oxidation, the desired Emmprin (34-94)-NH2 with chitobiose was successfully obtained. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3001 / 3004

页数：4

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