Ligand-Clustered "Patchy" Nanoparticles for Modulated Cellular Uptake and In Vivo Tumor Targeting

被引：134

作者：

Poon, Zhiyong ^{[1
]}

Chen, Shujun ^{[1
]}

Engler, Amanda C. ^{[1
]}

Lee, Hyung-il ^{[1
,2
]}

Atas, Evrim ^{[1
]}

von Maltzahn, Geoffrey ^{[3
]}

Bhatia, Sangeeta N. ^{[3
]}

Hammond, Paula T. ^{[1
]}

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] Univ Ulsan, Dept Chem, Ulsan 680749, South Korea

[3] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 40期

基金：

美国国家科学基金会;

关键词：

micelles; multivalency; nanoparticles; self-assembly; tumor targeting; FOLATE RECEPTOR; KB CELLS; BINDING; DELIVERY; THERAPEUTICS; ENDOCYTOSIS; EXPRESSION; MECHANISM; ADHESION; TISSUES;

D O I：

10.1002/anie.201003445

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A matter of presentation: The manner in which polyvalent ligands are presented to a cell-homogeneously or in spatially defined groupings on a nanoparticle surface-may play an important role in cellular uptake. This aspect is investigated for the first time using a linear dendritic polymer construct to pattern the surfaces of nanoparticles with variable-sized ligand clusters in different spatial arrangements. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：7266 / 7270

页数：5

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